感染性休克患者血浆弹性蛋白肽水平的变化及其意义

Change in plasma elastin peptide and its significance in patients with septic shock

目的观察感染性休克患者血浆中弹性蛋白肽(EP)水平的变化,探讨其在感染性休克期间血流动力学改变中所起的作用。方法采集18例感染性休克患者的血样,同时采集同期住院的36例非感染性疾病患者和18名正常人的血样,采用ELISA技术测量血浆弹性蛋白肽的浓度。结果与非感染性疾病患者及正常人相比,感染性休克患者休克期间血浆EP水平明显增高,而非感染性休克患者与正常人之间差异无统计学意义,感染性休克患者在休克好转后血浆EP水平较休克期间明显降低(P<0.05)。结论感染性休克患者在休克期间血浆EP水平明显增高,增高的EP可能参与了感染性休克血流动力学改变的病理生理过程。

Objective To observe the changes of plasma elastin peptide （EP） level in septic shock patients, and to investigate the effects that EP engender on the hemodynamlcs during septic shock. Methods Blood samples for EP measurement by ELISA were collected from 18 septic shock patients, 36 non-septic patients and 18 healthy persons. Results The plasma EP level during shock persistence period in septic patients was significantly higher than that in non-septic shock and healthy patients, which was similar in the latter two groups. The plasma EP level during shock recovery period was significantly lower than that during shock persistence period in septic patients. Conclusion The plasma EP level during shock persistence period in septic shock patients was significantly elevated, it may be invalved in the hemodynamie changes during septic shock.