匹维溴铵、金双歧治疗腹泻型肠易激综合征

Clinical Effect of Pinaverium Bromide and Jinshuangqi on Diarrhea Predominant Irritable Bowel Syndrome

目的观察匹维溴铵、金双歧治疗腹泻型肠易激综合征(IBS)的临床疗效。方法顺序随机选取本院门诊患者47例:试验组24例,对照组23例。诊断符合“罗马Ⅱ标准”,均排除器质性疾病。试验组口服匹维溴铵50 mg,3次/d,金双歧2.0 g,2次/d;对照组口服金双歧2.0 g,2次/d。比较治疗前、治疗期和停药随访期腹部症状总积分及每个主要症状积分并进行疗效评估。结果试验组治疗2周症状总积分由15.38±1.03下降至9.41±0.95(P<0.01),停药2周后为9.83±0.78,与治疗2周时疗效相比差异无统计学意义(P>0.05),停药2周后疗效仍可维持。对照组治疗2周症状总积分由15.01±1.16下降至11.89±1.08(P<0.01),停药2周后为14.32±1.17,与治疗2周时疗效相比差异有统计学意义(P<0.01),停药2周后疗效降低。结论联用匹维溴铵和金双歧较单用金双歧治疗腹泻型IBS在缓解腹胀、腹痛症状时疗效更明显、更明显。

Objective To investigate the curative effect of Pinaverium bromide and Jinshuangqi on diarrhea predominant irritable bowel syndrome（D-IBS）. Methods 47 patient with D-IBS by Roma Ⅱ diagnosis and non-organic disease in OPD were randomly divided into 2 groups ：24 patients in curative group takes Pinaverium bromide 50mg rid and Jinshuangqi 2. Og bid and 23 patients in control group takes Jinshuangqi 2. Og bid for 2 weeks. Reading the total scale scores of abdominal symptom and alone scale scores of abdominal distention, abdominalgia, defecation frequency, defecation disorder 1 week before treatment,2 weeks after treatment,and follow-up 2 week after stop treatment and evaluating the clinical effect. Results In curative group, the total scale scores of symptom was 15.38 ± 1.03 1 week before the treatment,that of returned to 9.41 ± 0.95 2 weeks after treatment, and was 9, 83 ± 0.78 follow-up 2 week after stop treatment. There was no significant difference （ P 〉 0.05 ）. In control group,the total scale scores of symptom was 15.01 ± 1.16 before the treatment,that of returned to 11, 89 ± 1.08 2 weeks after treatment, and was 14.32 ± 1.17 follow-up 2 week after stop treatment, respectively, There was significant difference （ P 〈 0. 01 ）. The abdominal distention, abdominalgia scale scores of the patients received the Pinaverium bromide and Jinshuangqi treatment de- creased more than that of the patients received the Jinshuangqi （P 〈 0.01 ）. Conclusions Both the Pinaverium bromide and Jinshuangqi treatment are helpful to improve the symptoms of IBS and had a longer efficacy time.