腻滞质与正常质高血压前期人群动脉弹性功能的对照研究

Comparison of Arterial Elasticity Between Phlegm-Dampness Constitution and Normal Constitution Prehypertensive People

目的:探讨腻滞质与正常质高血压前期人群动脉弹性的变化情况。方法:选择正常质、腻滞质理想血压健康者各30例;腻滞质高血压前期42例,正常质高血压前期36例;没有任何靶器官损害的1～2级腻滞质高血压患者38例,正常质高血压患者46例。使用CVProfilor DO-2020动脉弹性功能测定仪检测桡动脉脉搏波形和动脉弹性指数C1和C2,比较各组间大动脉、小动脉弹性及脉压差(PP)变化情况。结果:各组间C1、C2、PP比较,校正了年龄和病程后,高血压组与高血压前期、理想血压组相比较,C1明显降低,有显著性差异(P<0.05);高血压前期腻滞质、高血压组与理想血压组、高血压前期正常质组相比较,C2明显降低,有显著性差异(P<0.05);高血压正常质与高血压前期腻滞质组比较,C2明显降低,有显著性差异(P<0.05);高血压腻滞质组与高血压正常质组C2比较,C2明显降低,有显著性差异(P<0.05)。单因素相关分析结果显示:C1和C2与PP的相关性均较弱。结论:高血压前期患者已存在动脉弹性的减退;腻滞质可能是高血压病早期出现动脉弹性降低的重要因素。

Objective： To investigate the arterial elasticity of prehyportensive people with phlegm-dampness constitution and normal constitution. Methods： We collected healthy ideal blood pressure people with normal or phlegm-dampness constitution, thirty people each, 42 prehypertensive cases with phlegm-dampness constitution, 36 prehypertensive ones with normal constitution, and 38 Ⅰ-Ⅱ phase hypertension patients of phlegm-dampness constitution without any target organs damage, 46 hypertensive cases with normal constitution. Pulse wave of arteria radialis and arterial elastic indexes C1, C2 were detected by CVProfilor D0- 2020 arterial pulse contour instrument. Results： CI decreased in hypertensive patients compared with the ideal blood pressure groups and prehypertensive groups after adjustments for ages and disease durations; C2 decreased in prehypertensive people of phlegm-damp constitution and hypertensive patients, compared with the ideal blood pressure groups and prehypertensive people of normal constitution, P〈 0.05; C2 decreased in hypertensive patients of normal constitution, compared with prehypertensive people of phlegm-damp constitution,P〈0.05; C2 decreased in hypertensive patients of phlegm-damp constitution, compared with hypertensive patients of normal constitution,P〈 0.05. There was no significant correlation between CI and C2 in pulse pressure. Conclusions： Small arterial elastic index （C2） decreases in prehypertensive people; phlegm-damp constitution may play an important role in depressed arterial elasticity of early hypertension.