肥胖与急性高原病关系的研究

Association between obesity and acute high-altitude disease

目的:探讨肥胖对急进高原者的影响。方法:总共39名肥胖和43名非肥胖的中青年男性入选本试验。参试者需在平原及进入高原12、24h完成高山反应自我评价表,测量身高、体重,计算体重指数,测量肺活量,抽静脉血测定血红蛋白。在平原和进入高原后24h分别抽动脉血测定氧饱和度、氧分压、二氧化碳分压。结果:两组比较,年龄、血红蛋白、肺活量无统计学差异(P>0.05)。两组的体重指数差异明显,是因为这是本实验分组的截断点。在平原地区两组间氧饱和度、氧分压、二氧化碳分压无差异。但进入高原后24h,肥胖组的氧饱和度、氧分压明显低于非肥胖组,二氧化碳分压显著高于非肥胖组(P<0.001)。结论:肥胖是发生急性高原病的重要危险因素。

Objective： To investigate the effect of obesity on subjects with acute high-altitude exposure. Methods： A total of 39 obese and 43 nonobese young-middle aged male subjects were enrolled in this study. Each subject completed an AMS （acute mountain sickness） self-report questionnaire at sea level and after ascending high-altitude 12 hours and 24 hours. Weight and height were measured and BMI was calculated. Vital capacity of lungs was measured. Venous blood was sampled for measuring hemoglobin at baseline. Arterial blood was taken for evaluating arterial oxygen saturation （SO2）, arterial oxygen pressure （PaO2） and arterial carbon dioxide pressure （PaCO2） at baseline and 24 hours after ascending high-altitude. Results： No statistical differences were found between groups at age, hemoglobin and vital capacity （P〉0.05）. BMI in the two groups was significantly different because it is the cut-off point of grouping. At sea level, no statistical differences were found between groups at SO2, PaO2, PaCO2, but 24 h after ascending high-altitude, SO2, PaO2 were much lower and PaCO2 was significantly higher in obese group than those in nonobese group （P〈0.001）. Conclusion： Obesity is an important risk factor in the development of acute high-altitude disease.