心绞痛患者血肿瘤坏死因子及C反应蛋白浓度的变化

Change of serum level of TNF-α and CRP in patients with unstable angina

目的:探讨检测不稳定型心绞痛(UAP)患者血清肿瘤坏死因子(TNF-α)和C反应蛋白(CRP)的临床意义。方法:采用酶联免疫吸附法(ELISA)及免疫透射比浊法,检测38例UAP、30例稳定型心绞痛(SAP)患者及30例健康者血清中TNF-α和CRP含量。结果:①UAP患者血TNF-α和CRP水平均较SAP患者及健康者显著升高(P<0.01),SAP组的也高于健康组(P<0.01);②单因素回归分析发现CRP与TNF-α之间有显著正相关(r=0.62,P<0.01)。结论:不稳定心绞痛患者存在炎性细胞活化和炎症反应,TNF-α与CRP可作为冠状动脉粥样病变不稳定的诊断指标。

Objective：To explore the clinical significance of tumor necrosis factor α（TNF-α） and C-reactive protein （CRP） in patients with unstable angina（UAP）. Methods：Serum levels of TNF-α and CRP were determined in 38 patients with UA P（UAP group）、30 patients with stable angina （SAP group） and 30 healthy （health group） by immunoturbidimetry and ELISA. Results： Serum levels of TNF-α and CRP were significantly higher in patients with UAP than those in patients with SAP and healthy（P〈0.01 all）, those of SAP group also more than those of heath group（P〈0.01）;② Regression analysis shows significantly positive correlation between TNF-α and CRP （r=0. 62, P〈0.01）. Conclusion： The results demonstrate that there are activation of inflammatory cells and inflammation in patients with UAP, serum levels TNF-α and CRP can be used as marked of unstable coronary artery pathological change.