摘要
用氯化十六烷基吡啶(Cetylyridinium Chloride,CPC)对变形链球菌、白色念珠菌、血链球菌、乳酸杆菌、粘性放线菌、草绿色链球菌、奈瑟氏菌、枯草杆菌、大肠杆菌、金葡菌10菌株。和甲硝唑(Metromidazolum,MTZ)对脆弱类杆菌、产黑类杆菌、梭形杆菌、龈类杆菌、放射菌、消化链球菌6菌种、35株分别进行抑菌实验。结果表明:CPC除对白色念珠菌和奈瑟氏菌有耐药性外,其余菌种均十分敏感,MIC为5～6.25tμg/ml。MTZ对厌氧菌高度敏感,其MIC为0.625～10μg/ml,因此该含漱剂对需氧菌、兼性厌氧和厌氧菌有明显作用,适用于口腔感染性疾病的辅助治疗.有推广应用价值。
The bacteriostatic effects of eetylpyridinium chloride (CPC) and metronidazole (MTZ) on 16 strains belonging to oral organisms were carried out . It showed that S. mutans ,A. viscosus. Lactobacillus ,S. sanguis ,Escherichia coli ,Staphy aureus ,S. viridance and B. subtilis were sensitive to CPC with MIC 5-6.25μg/ml whereas B. fragilis ,B. melaninogenicus ,B. gingivalis, B. fusiformis ,Peptostreptococcus and Aetinomyces were sensitive to MTZ with MIC 0.625-10μg/ml. However,Candida albicous and Nisseria were resistant to CPC. It is suggested Hu Chi mouthrinse containing CPC and MTZ might be a supplementary agent in the treatment of gingivitis and periodontitis.
关键词
含漱剂
抑菌作用
牙龈炎
甲硝唑
CPC
Mouthrinse
Bacteriostatic effect
Gingivitis
Cetylpyridinium chloride
Metronidazole
