脑外科院内感染与抗菌药应用的相关性分析

Correlative analysis Between the Application of Antibacterial in the Craniocerebral Surgical Drugs and Nosocomial Infection in Brain Surgery

目的:探讨颅脑手术患者抗菌药的应用与院内感染的相关性,以期指导临床合理应用抗菌药。方法:对我院2002年1月～2005年6月604例颅脑手术患者的病历进行回顾性调查,对临床标本病原学检查和药敏试验结果进行统计学处理。结果:604例中发生院内感染40人(感染率6.62%),46例次(例次率7.62%)。以上、下呼吸道感染为主(63.6%)。共检出致病菌74株,发生医院感染的致病菌主要为G^-杆菌,共44株(59.8%)。结论:颅脑外科术后发生医院内感染与多重因素有关,而抗菌药的非理性应用是重要因素之一。

Objective： To evaluate the correlation between the application of antibacterial drugs and nosoeomial infection_in brain surgery. Method： The medical records of 604 patients with craniocerebral operation from January 2002 to June 2005 were investigated retrospectively, and the results of identification of pathogens and sensitivity tests on clinical sample were analyzed statistically. Result： Among the 604 eases,40 patients and 46 times were belong to nosocomial infection （ the infection rate was 6.62% and the incidence of nosoeomial infection was 7.62% ）. Upper and lower respiratory tract infection was the main reason（63.6% ）. 74 strains of pathogenic bacterial were found out. The pathogenic bacterial leading to nosoeomial infection were mainly G-bacilus（44strains,59.8% ）. Conclusion： Nosocomial infection niter brainsurgery is related to many factors, one of the inportant factors is the unrational use of anti-bacterial drugs.