顺铂联用吉西他滨或长春瑞滨治疗非小细胞肺癌术后患者近期疗效观察

Observation of chemotherapy with GP and NP on post-operative patients of non-small cell lung cancer

目的观察非小细胞肺癌术后患者采用顺铂联用吉西他滨或长春瑞滨方案（GP或NP方案）化疗的近期疗效和不良反应。方法选取85例非小细胞肺癌术后患者，随机分为GP化疗组和NP化疗组，观察两组患者在化疗期间的死亡率、转移、复发和化疗毒副反应发生情况。结果化疗期间非化疗原因死亡3例，GP组2例．NP组1例。复发：GP组2例，NP组1例。转移：GP组6例．NP组7例。近期疗效两组无明显差异。两组化疗的主要毒性反应均为骨髓抑制和恶心、呕吐。GP组血小板减少高于NP组；NP组白细胞减少和血红蛋白下降高于GP组：两组恶心．呕吐的发生率相似。两者毒副作用均可耐受。结论GP和NP方案均可作为非小细胞肺癌术后患者化疗的一线方案，前者毒副作用低于后者。

Objective To observe the effect and toxiclries of chemotherapy with GP and NP on post-operative non-small cell lung cancer（NSCLC） patients. Methods 85 post-operative patients of NSCLC were divided into 2 groups randomly ：GP treatment group and NP treatment group. The death rate, metastasis, recrudescence and toxi- cities in two groups were observed. Results 3 non chemotherapy-related death were found in 2 groups,2 in group GP and 1 in group NP;Recrudesccnce occured in 2 palients in group GP, 1 in group NP;Merastasis occured in 6 parients in group GP, 7 in group NP. The therapeutic effect in two groups was similar. The major roxicities in two groups were marrow suppressing and chemotherapy-induced nausea and vomiting（CINV）. More platelet depressing patients were found in group GP;But the ratio of leukocyte and hemachrome depressing was higher in group NP; The ratio of CINV was similar in two groups. The toxicities of two methods were all durable. Conclusion Either GP or NP can be used in chemotherapy on post-operative NSCLC palients,the side effects are less in the former.