氧气驱动雾化吸入沙丁胺醇、氨溴索治疗婴幼儿下呼吸道感染

Utilization of saibutamoi sulfate and mucosoivan in the treatment of patients with ALRTI

目的探讨硫酸沙丁胺醇、氨溴索在急性下呼吸道感染治疗中的疗效。方法急性下呼吸道感染患儿102例，随机分为治疗组和对照组两大组。治疗组70例分为A、B两个方案组，用氧气驱动雾化吸入治疗，药物配伍分别为：氨溴索（沐舒坦注射液，15mg／2ml）；0．5％硫酸沙丁胺醇雾化溶液0．25ml＋氨溴索（沐舒坦注射液，15mg／2ml）。对照组32例，给予a-糜蛋白酶5mg。结果A方案组、B方案组和对照组三组的总有效率分别为82．85％、91．42％、59．38％。A方案组与B方案组两者有效率对比差异无统计学意义（P〉0．05），但与对照组比较，则差异有统计学意义（P〈0．05）；三组的显效率分别为54．29％、77．14％、31．25％，B方案组的显效率与A方案组、对照组比较差异有统计学意义（P〈0．05）。从临床症状、体征缓解时间、平均住院日比较，治疗组均优于对照组（均P〈0．05）；B方案组的主要临床症状、体征缓解时间又优于A方案组（P〈0．05）。结论在急性下呼吸道感染患儿采用氧气驱动雾化吸入沙丁胺醇加氨溴索，有助于病情缓解。

Objective To investigate the efficacies of salbutamol sulfate and mucosolvan in the treatment of children with ALRTI. Methods 102 patients with ALRTI were randomly assigned into A,13 treatment groups and control group（ n = 32 ）. Group A, group 13 received the inhalation of oxygen-driven aerosols of 15mg/2ml mucosoldan;0.5 % salbutamol sulfate 0.25ml plus 15mg/2ml mucosolvan respectively and control group received 5rag ehymotrypsin. Results The global effective rates of A,13 and control groups were 82.85 % ,91,42 %, 59.38 % respectively. No significant difference was observed between group A and group B（P 〉 0.05）. But treatment groups were significantly better than the control group（ P〈0.05）;The effective rates of A, B and control groups were 54.29 %, 7.14 %, 1.25 % respectively. The effective rate of group 13 was significantly higher than those of group A and control group（P 〈0.05）. There were significant differences between A,B treatment groups and control group in the mean time spent to attain symptomatic relieving（P 〈0.05）. However,B group differed significantly with that of group A （P 〈0.05）. Conclusion The combined inhalation of oygen-driven aerosols of 0.5 % salbutamol sulfate and mucosolvan may afflor a better benefit to the children with ALRTI.