2型糖尿病合并抑郁患者血皮质醇水平变化的研究

Study of the cortisol level in type 2 diabetes patients with depression

目的研究抑郁对老年2型糖尿病患者血浆皮质醇水平的影响。方法将被试人员分为非糖尿病非抑郁组(对照组)、非糖尿病抑郁组、糖尿病非抑郁组、糖尿病抑郁组,测定血浆皮质醇和血糖。利用Zung抑郁自评量表得分,计算出抑郁严重度指数。结果①与对照组相比,其他三组皮质醇(8Am、平均水平)差异有显著性(P<0.01);糖尿病抑郁组与非糖尿病抑郁组相比,皮质醇(4Pm、0Am、平均水平)差异有显著性(P<0.05);糖尿病抑郁组与糖尿病非抑郁组相比,皮质醇(4Pm、平均水平)差异有显著性(P<0.05)。②糖尿病非抑郁组与对照组相比抑郁严重度指数升高(P=0.001)。糖尿病抑郁组与非糖尿病抑郁组相比抑郁严重度指数稍高,但无统计学意义。③多元线性回归结果显示抑郁严重度指数与皮质醇平均水平,年龄呈正相关,与腰围呈负相关。结论糖尿病与抑郁均伴血皮质醇水平升高。其中糖尿病合并抑郁者血皮质醇水平升高更明显。抑郁严重度指数与皮质醇平均水平呈正相关。

Objective to study the change of cortisol in the patients of diabetes mellitus with depression. Methods The experimenters were divided into four groups. There are （ 1 ） the group without diabetes or depression （ control group） （2） depression group without diabetes （3） diabetes group without depression （4） diabetes group with depression. The level of cortisol （8 Am ,4 Pm ,0 Am） and the blood sugar were measured. The index of the depression severity was calculated by the score of the Zung＇s self-rating depression scale （SDS）. Results （1）Compared with the control group, the cortisol of 8Am and the average level in the other three groups elevated significantly （ P 〈 0. 01 ）. Compared with depression group without diabetes,the cortisol of 4 Pm, 0 Am and the average level in the diabetes group with depression elevated significantly （ P 〈 0. 05 ）. Compared with diabetes group without depression, the cortisol of 4 Pm and the average level in the diabetes group with depression elevated significantly （ P 〈 0. 05 ）. （2）The index of the depression severity in diabetes group without depression is significantly higher than that of the control group （P =0. 001 ）. That of the group of diabetes with depression is slightly higher than that of depression group without diabetes, but had no significance. （3）Multiple linear regression analysis showed that the index of depression severity was positive correlation with the average level of cortisol, age, and was negative correlation with the waist circumference. Conclusion Diabetes and depression correlate with the elevation of the cortisol level. The level of cortisol in diabetes group with depression elevate more significantly. The index of depression severity is positive correlation with the average level of cortisol.