摘要
目的:探讨血管内皮生长因子(VEGF)在正常妊娠及子痫前期孕妇血清中水平与妊娠结局的关系。方法:采用酶联免疫吸附试验(ELISA)检测69例子痫前期患者(其中轻度37例,重度32例)的外周血(静脉血)VEGF水平,并与58例正常孕妇作对照。结果:子痫前期孕妇血清中VEGF水平较正常对照组低(p<0.05),重度子痫前期孕妇血清中VEGF水平也明显低于正常对照组(p<0.001)。比较子痫前期孕妇与正常孕妇的妊娠结局,两者在宫高,腹围,胎儿双顶径,新生儿体重,1分钟Apgar评分,羊水Ⅱ-Ⅲ污染度,胎盘重量均存在差异。结论:子痫前期患者VEGF的改变,会引起内皮细胞激活和损伤,从而导致高血压,蛋白尿等临床症状,并对围产儿的结局有一定影响。
Objective： In order to understand the relationship of pregnancy outcome and vascular endothelial growth factor（VECF） level in serum of normal pregnancy and pregnancy with pre-eclampsia. Methods： VECF levels in serums of 69 cases of pregnancies with pre-eclampsia （37 cases were mild pre-eclampsia, 32 cases were severe pre - eclampsia） were tested with E LISA. Fifty eight cases of normal pregnancy were used as control. Results ： VEGF levels in serums of pregnancies with mild pre-eclampsia were significantly lower than that of normal pregnancy （ p 〈 0. 05）. VECF levels in serums of pregnancies with severe pre-eclampsia were also significantly lower than that of normal pregnancy （p 〈0. 001 ）. Compared the outcome of normal pregnancy and pregnancy with pre- eclampsia, there were significant differences between these two groups in name of fundal height uterus, abdomen circumference, biparietal diameter, birth weigh＇t, Apgar score, contamination of amniotic fluid, placental weight. Conclusion： Change of VECF levels in serums of pregnancies with pre-eclampsia would activate and damage endothelials and result in hypertension, protein urine ,which could deteriorate outcome of fetus.
