孕期和非孕期黄褐斑患者血清铜、红细胞锌、T_3、T_4的分析

Detection of serum cuprum,erythrocyte zinc,T_3,T_4 and its clinical significance

目的:探讨黄褐斑的发生与甲状腺激素、微量元素的关系。方法:用原子吸收分光光度法测定了孕期和非孕期黄褐斑患者和对照组血清铜,红细胞锌,用放免法测定血清中T3、T4的含量。结果:1、孕期黄褐斑患者血清中T3、T4明显高于对照组,二者有显著性差异(P<0.01)。非孕期黄褐斑患者血清中T4明显高于对照组,二者有显著性差异(P<0.05)。2、孕期和非孕期黄褐斑患者血清铜明显高于对照组,二者均有显著性差异(P<0.01)。3、孕期和非孕期黄褐斑患者红细胞锌明显低于对照组妇女。结论:血清铜、甲状腺激素升高、红细胞锌降低,可能是黄褐斑产生的主要原因。

Objective ：To investigate the association of the cause of melasma with thyroxin and microelement. Methods：Serum cuprum, erythrocyte zinc in pregnant and non - pregnant patients with melasma and control were detected by using atomic absorption spectrometry, and the content of T3, T4 in serum detected by radio immunoassay. Results： 1. The levels of serum T3, T4 in pregnant patients was significantly higher than that in control （ P 〈 0. 01 ）, and the level of serum T4 in non - pregnant patients was significantly higher than that in control （ P 〈 0. 05 ）. 2. The level of serum cuprum in pregnant and non - pregnant patients was significantly higher than that in control （P 〈 0. 01 ）. 3. The level of serum zinc in pregnant and non - pregnant patients was significantly lower than that in control Conclusion：The increasing of serum cuprum, thyroxin and the decreasing of serum zinc maybe the main cause of melasma.