趋化因子CXCL12及其受体与肿瘤转移的关系

Correlations of Chemokine CXCL12 and Its Receptor to Tumor Metastasis

趋化因子CXCL12(C-X-C chemokine ligand 12)及其受体CXCR4(c-x-c chemokine receptor4)在胚胎发育、干细胞的迁移和各种免疫反应中发挥重要作用,是许多生理和病理过程中指导细胞运动的中心因素。最近发现肿瘤细胞的转移机制和白细胞的迁移相类似,趋化因子CXCL12及其受体与肿瘤的生长、侵袭、转移和分泌密切相关,动物实验表明CXCR4可能成为抑制肿瘤生长、转移的重要靶目标。本文将对趋化因子CXCL12及其受体CXCR4在肿瘤转移、进展中的作用以及与此相关的信号转导、调节因子进行综述。

Previous studies suggest that chemokine CXCL12 and its receptor CXCR4 play important roles in embryonic development, stem cell trafficking, and inflammatory reactions. It is a central factor in directing cell movement of many physiologic and pathologic processes. The mechanisms of cancer cell metastasis and white blood cell trafficking are similar. CXCL12- CXCR4 axis exerts important effects in regulating growth, invasion, metastasis, and secretion of malignant cells. Data from animal experiments suggest that CXCR4 may be an important therapeutic target in inhibiting malignant growth and metastatic behavior of tumor cells. This review focused on the role of CXCL12-CXCR4 axis in regulating tumor metastasis and progression, and the molecular mechanisms that are essential to this process.