磷酸化胞嘧啶鸟嘌呤基序的脱氧寡核苷酸对尘螨支气管哮喘小鼠早期防治探讨
被引量：1
摘要
近年发现含磷酸化胞嘧啶鸟嘌呤基序（CpG）的脱氧寡核苷酸（CpGODN）具有免疫调节作用，可增强Th1和抑制Th2细胞反应，在抗原提呈阶段即发挥作用，我们采用尘螨抗原制作小鼠哮喘模型，探讨CpGODN的早期防治作用。
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2007年第2期147-148,共2页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
浙江省卫生厅优秀青年科技人才专项基金资助(SYO97001)
参考文献5
-
1Klinman DM.Immunotherapeutic uses of CpG oligodeoxynucleotides.Nat Rev Immunol,2004,4:249-258.
-
2Beloeil L,Tomkowiak M,Angelov G,et al.In vivo impact of CPG1826 oligodeoxynucleotide on CD8 T cell primary responses and survival.J Immunol,2003,171:2995-3002.
-
3Hessel EM,Chu M,Lizcano JO,et al.Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction.J Exp Med,2005,202:1563-1573.
-
4Kline JN,Waldschmidt TJ,Businga TR,et al.Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.J Immunol,1998,160:2555-2559.
-
5Broide D,Schwarze J,Tighe H,et al.Immunostimulatory DNA sequences inhibit IL-5,eosinophilic inflammation,and airway hyperresponsiveness in mice.J Immunol,1998,161:7054-7062.
同被引文献19
-
1Paust S,Cantor H. Regulatory T cells and autoimmune disease[J]. Immunol Rev, 2005,204 : 195-207.
-
2Hori S ,Nomura T,Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3[J]. Science,2003,299 (5609) : 1057-1061.
-
3Campbell DJ,Ziegler SF. Foxp3 modifies the phenotypic and functional properties of regulatory T cells[J]. Nat Rev Immunol, 2007,7 (4) : 305-310.
-
4Wilson HL,Dar A,Napper SK,et al. Immune mechanisms and therapeu- tic potential of CpG oligodeoxyuueleotides[J]. Int Rev Immunol, 2006,25 (3-4) : 183-213.
-
5Gupta GK,Agrawal DK. CpG oligodeoxynucleotides as TLR9 agonists: therapeutic application in allergy and asthma[J]. BioDrugs ,2010,24 (4) :225-235.
-
6Fonseca DE,Kline JN. Use of CpG oligonucleotides in treatment of asth- ma and allergic disease[J]. Adv Drug Deliv Rev,2009,61 (3):256-262.
-
7Clarke AH,Thomas WR,Rolland JM,et al. Murine allergic respiratory responses to the major house dust mite allergen Der p l[J]. Int Arch Al- lergy Immunol, 1999,120(2) : 126-134.
-
8Hartl D,Koller B,Mehlhorn AT,et al. Quantitative and functional im- pairment of pulmonary CD4+CD25+i regulatory T cells in pediatric asth- ma[J]. J Allergy Clin Immunol,2007,119(5):1258-1266.
-
9Provoost S,Maes T,van Durme YM,et al. Decreased Foxp3 protein ex- pression in patients with asthma[J]. Allergy, 2009,64 ( 10 ) : 1539-1546.
-
10Karagiannidis C ,Akdis M, Holopainen P,et al. Glucocorticoids upreg- ulate FOXP3 expression and regulatory T cells in asthma[J]. J Allergy Clin Immuno1,2004,114(6) : 1425-1433.
-
1王启朋,陈仲伟,冯航.腮腺多形性腺瘤的手术治疗及并发症防治探讨[J].广东牙病防治,1997,5(3):36-37.
-
2苏秀瑛,杨钦水.儿童急性白血病诱导缓解和巩固治疗合并感染防治探讨(附69例报告)[J].白血病,1999,8(5):305-306.
-
3廖德富,吴进.食管、贲门癌14例术后吻合口瘘的防治探讨[J].安徽医科大学学报,1997,32(3):286-286.
-
4冯起校,李七郎,辛小川,张旭昌,单晓宇,谭戈峰,张春芳,甘惠兰.肺癌急症的防治探讨[J].中国危重病急救医学,1997,9(1):38-40. 被引量：1
-
5卢榜裕,卢全书,王文光,郑建国.胃癌术后并发症的原因及防治探讨[J].广西医学,1991,13(4):221-223. 被引量：1
-
6施玉辉.肝癌手术病人院内感染的防治探讨[J].右江医学,1998,26(3):209-209.
-
7程立,殷莲华.SRS白血病病毒的分子生物学和反义脱氧寡核苷酸抗病毒作用[J].中国病理生理杂志,1993,9(4):545-547.
-
8陈协群,黄高升,杨平地,胡盛惠.bcl-2反义脱氧寡核苷酸对白血病细胞生长与凋亡易感性的影响[J].中国肿瘤临床,1997,24(1):9-12. 被引量：2
-
9李飞,刘剑波.干扰素-γ对支气管哮喘小鼠气道杯状细胞化生及其分泌黏蛋白Muc5ac的影响[J].中华结核和呼吸杂志,2008,31(7):534-535. 被引量：1
-
10张双林,张庄,赵建军.食管贲门癌术后单纯性脓胸的防治探讨[J].中华医院感染学杂志,1999,9(2):102-103. 被引量：1
