胆固醇/高密度脂蛋白-胆固醇比值与脑梗死发病危险性间关系

The relationship between the ratio of TC/HDL-C and the risk of ischemic stroke

目的探讨胆固醇/高密度脂蛋白-胆固醇比值(TC/HDL-C比值)的高低与脑梗死发病危险性之间的关系,以及这一比值与年龄增长之间的相关性。方法采用回顾性病例对照研究,用全自动血生化分析仪测量各项生化指标,对228例脑梗死患者和229例非脑梗死对照者的血生化指标进行统计分析。结果(1)病例组和对照组的年龄、性别无显著性差异,两组尿素氮(BUN)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、脂蛋白a[Lp(a)]水平无显著性差异(P>0.05);(2)常见脑梗死危险因素如家族史、吸烟史、饮酒史、高血压病史、糖尿病史、病例组明显高于对照组(P<0.05);(3)脑梗死组胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白-胆固醇(LDL-C)水平显著高于对照组(P<0.05),而高密度脂蛋白-胆固醇(HDL-C)水平显著低于对照组(P<0.05),两组血糖水平有显著性差异(P<0.05);(4)病例组的TC/HDL-C比值为(4.26±1.20)mmol/L,对照组为(4.06±1.26)mmol/L。Logistic回归分析显示,调整年龄性别等变量后脑梗死组TC/HDL-C比值显著高于对照组(P<0.05);(5)病例组和对照组合并后按年龄分为四组,对各年龄段组的TC/HDL-C比值进行两两比较,组间没有显著性差异(P>0.05)。结论血浆TC/HDL-C比值≥4.26可能是脑梗死的一个独立危险因素,且这一比值不随年龄的增长而改变。

Objective To investigate the relationship between the plasma TC/HDL-C ratio and the risk of ischemic stroke and the relationship between the plasma TC/HDL-C ratio and the age. Methods A casecontrol study on 228 patients with ischemic stroke and 229 healthy controls was studied. The blood-samples of 228 patients and 229 controls were analyzd by complete automatic blood-biochemistry analyzer. Results （ 1 ） There was no significant difference in age and sex between the patients and the controls. The level of blood urea nitrogen and alanine aminotransferase and aspartate aminotransferase in patients with ischemic stroke had no significant difference with the controls. And the level of lipoprotein a in patients with ischemic stroke had no significant difference with the controls; （2）The common risk factors such as family history, cigarette smoking and alcohol intaking, hypertension history, diabetes mellitus history in patients were significantly more than those in the controls（P〈0. 05） ; （3）The level of plasma cholesterol, triglycerides, low-density lipoprotein cholesterol, blood sugar in ischemic stroke patients was higher than the controls. And the level of high density lipoprotein cholesterol was lower than the controls; （4）The ratio of TC/HDL-C in patients was （4. 26 ± 1.20） mmol/L, and the controls was （4. 06 ± 1.26）mmol/L. Logistic congress analysis indicated, after adjusted by age and sex, the ratio of TC/HDL-C in ischemic stroke patients was higher than the controls;（5）We analyzed the plasma TC/HDL-C ratio in different strate of age,and no significant difference was found. Conclusiom Plasma TC/HDL-C ratio may be an independent risk factor for ischemic stroke,and this ratio do not change with age.