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中枢神经系统髓磷脂抑制信号传导机制研究进展 被引量：1

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摘要 大量研究表明中枢神经损伤后早期轴突再生失败的主要原因是髓磷脂抑制因子的存在。目前在中枢神经系统(central nervous system,CNS)中,已知的抑制因子有勿动蛋白Nogo、髓鞘相关糖蛋白(myelin-associated glycoprotein,MAG)和少突胶质细胞髓鞘糖蛋白(oligodendrocyte-myelin glycoprotein,OMgP)。本文主要就这些因子所介导的中枢神经再生抑制信号的传导机制作一综述,以期为在分子水平阻断轴突再生抑制因素的治疗提供确切的干预靶点。
作者 王锋 王玮
机构地区 福建医科大学人体解剖学与组织胚胎学系
出处 《解剖学研究》 CAS 2007年第1期65-67,共3页 Anatomy Research
关键词 髓磷脂 勿动蛋白 髓鞘 信号转导 轴突
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献17

  • 1Wang KC, Koprivica K, Kim JA, et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature, 2002,417 : 941-944.
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同被引文献25

  • 1Cao ZX, Gao Y, Deng KW, et al. Receptors for myelin inhibitors: Structures and therapeutic opportunities[J]. Molecular and Cellular Neuroscience, 2010, 43(1): 1-14.
  • 2Chaudhry N, Filhin MT. Myelin - associated inhibitory signaling and strategies to overcome inhibition[J]. Journal of Cerebral Blood Flow & Metabolism, 2007, 27:1096-1107.
  • 3Akbik F, Cafferty B J, Strittmatter M. Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity [J]. Experimental Neurology, 2012, 235(1): 43-52.
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  • 5Wang T, Xiong JQ, Ren XB. The role of Nogo-A in neuroregeneration: A review[J]. Brain Research Bulletin, 2012, 87: 499-503.
  • 6Anna J, Mariola M. Soluble Nogo-A, an inhibitor of axonal regenera- tion, as a biomarker for multiple sclerosis[J]. Neuron, 2007, 68:283 -287.
  • 7AtwaI JK1. PirB is a functional receptor for myelin inhibitors of axonal regeneration[J]. Science, 2008, 322(5903): 967-970.
  • 8Hu F, Strittmatter SM. The N-terminal domain of Nogo-A inhibits cell adhesion and axorud outgrowth by an integrin-specific mechanism[J]. J Neurosci, 2008, 28(5):1262-1269.
  • 9Schwab ME. Nogo and axon regeneration[J]. Curr Opin Neurobiol, 2004, 14: 118-124.
  • 10Vargas ME, Barres BA. Why is Wallerian degeneration in the CNS so slow[J]. Annu Rev Neurosci, 2007, 30(1): 153-179.

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解剖学研究
2007年 第1期

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