聚L-乳酸/β-磷酸三钙复合骨支架材料成型工艺优化研究

Study on molding technology optimization of preparing porous poly(L-lactic acid)/β-tricalcium phosphate composite scaffold materials

利用溶剂自扩散-模压成型-粒子沥滤法制备聚L-乳酸（PLLA）／β-磷酸三钙（β-TCP）复合多孔支架材料，采用正交设计对成型工艺进行了优化，对支架进行了形貌观察、力学强度和孔隙率大小测试。结果表明：当PLLA：β-TCP=1：2，成型压力5MPa，致孔剂粒径125～400μm，用量80％（wt）时，制备的支架材料孔结构三维贯通，抗压强度为4．45MPa、孔隙率为60．7％，满足骨组织工程支架材料要求。

Porous poly（L-lactic acid）（PLLA）/β-tricalcium phosphate（β-TCP） composite scaffold was fabricated by using the method of solvent self-diffusion, compression molding and leaching. The orthogonal design was used to optimizing the molding technology. Composite scaffold was characterized by SEM observation, the mechanical strength and porosity were tested. The results showed that the pores structure of composite scaffold was interconnected, the compressive strength was 4. 45MPa and porosity was 60. 7% ,which was fabricated under technology that PLLA：β-TCP = 1 ： 2, molding compression was 5MPa, the particle size of porogen was 125～400μm and percentage content was 80 % （wt）. These properties could meet the needs of bone tissue engineering.