萎缩性胃炎白细胞介素-1β水平和幽门螺杆菌感染的意义

Serum Interleukin-1β and HP Infection in Atrophic Gastritis

目的探讨白细胞介素-1β（IL-1β）在萎缩性胃炎发病机制中的作用，以履IL—1β和幽门螺杆菌（HP）感染的关系．方法选择浅表性胃炎患者52例，萎缩性胃炎患者50例，试验分4组：A组：汽表性胃炎并HP阴性；B组：浅表性胃炎并HP阳性；C组：萎缩性胃炎并HP阴性；D组：萎缩性胃炎并HP阳性．采用酶联免疫吸附实验法（ELISA法）检测患者血清IL-1β水平，采用140尿素呼吸实验方法（14C-uBT）判定HP感染情况，结果萎缩性胃炎患者血清IL-1β水平均高于浅表性胃炎，尤其萎缩性胃炎伴HP感染阳性患者血清IL-1β水平升高明显，显著高于浅表性胃炎患者（P〈0．01）．与元HP感染的萎缩性胃炎患者相比，其血清IL-1β水平也明显升高（P〈0．05）．血清IL-1β水平在浅表性胃炎患者中有HP感染比无HP感染的患者也有升高趋势。但元显著性差异（P〉0.05），绪论在萎缩性胃炎的发病机制中IL-1β是关链的功能细胞因子，并可能是HP感染导致萎缩性胃炎的相关发病机制之一，

Objective To observe the effect of interleukin-1β（IL-1β） in atrophic gastritis and to identify the relationship between IL-1β level and helicobacter pylori（HP） infection. Methods 52 cases of superficial gastritis and 50 cases of atrophic gastritis were investigated. The trail has four groups： group A： superficial gastritis with HP negative subjects; group B： superficial gastritis with HP positive subjects; group C： atrophic gastritis with HP negative subjects; groups D： atrophic gastritis with HP positive subjects. Serum IL-1β level was examined by enzyme-linked immunosorbent assay. HP infection was determined by 14C-urea breath test（14C-uBT）. Results Serum IL-1β levels in atrophic gastritis were higher than those in superficial gastritis. Especially serum IL-1β in atrophic gastritis with HP positive subjects（P 〈 0.01）and atrophic gastritis with HP negative subjects（P 〈 0.05）. In superficial gastritis with HP infection serum IL-1β were higher than HP negative subjects, but there was no significance （P 〉 0.05）. Conclusion iL-1β may contribute to the pathogenesis of atrophic gastritis. Inducible generation of IL-1β may one of the mechanisms to explain the link between HP infection and atrophic gastritis.