微卫星不稳定性与胃癌的发展
摘要
DNA错配修复（MMR）缺陷与许多癌症的发生有关。细胞MMR缺陷会导致广泛的遗传突变及肿瘤的发生和发展。MMR缺陷肿瘤的一项重要诊断学特征为核苷酸重复区域高突变率的累积，这些突变即微卫星不稳定性（MSI）。现就近年来国内、外关于MSI与胃癌发生、发展的研究进展综述如下。
出处
《上海医学》
CAS
CSCD
北大核心
2007年第1期68-70,共3页
Shanghai Medical Journal
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