密集方案新辅助化疗对乳腺癌细胞凋亡的影响

The Effects of Dose-dense Neoadjuvant Chemotherapy for the Apoptosis of Breast Cancer

目的:探讨密集方案新辅助化疗临床效果及对乳腺癌细胞凋亡的影响。方法:44例乳腺癌患者随机分成CEF14组和CEF21组,分别接受CEF14方案和CEF21方案新辅助化疗,观察其临床结果;使用TUNEL法观察各组标本化疗前后细胞凋亡指数,以分析不同密度化疗方案对乳腺癌细胞凋亡的影响。结果:最终35例完成了既定方案化疗,CEF14组临床有效率为50.00%(9/18),CEF21组临床有效率为41.18%(7/17)(P>0.05)。CEF14组、CEF21组化疗前凋亡指数分别为(6.36±1.05)、(7.40±3.93)(P>0.05);化疗后分别为(24.00±12.00)、(17.52±7.00)(P>0.05),两组化疗前后比较均有统计学意义(P<0.05)。结论:密集方案新辅助化疗与常规方案新辅助化疗有相似的临床效果,均能诱导肿瘤细胞的凋亡增加。

Objective：To evaluate the effect of dose-dense neoadjvant chemotherapy on the clinical results and apoptosis in breast cancer tissues. Methods：44 patients of breast cancer were randomly divided into CEF,4 group and CEF21 group and received CEF,4 or CEF21 neoadjuvant chemotherapy respectively. The clinical results of the two groups were observed and then TUNEL methods to detect the AI of the two groups were used to analyze the effects of different chemotherapy on the AI of the breast cancer tissues. Results：35 patients finished the scheduled chemotherapy as planned. Clinical efficacy rate in CEFI4 group was 50% （9/18） ,and 41.14% （7/17） in CEF21 group （P 〉0. 05）. The apoptosis index before chemotherapy in CEFI4 and CEF21 group was （6.36 ± 1.05 ） and （7.40 ± 3.93 ） （ P 〉 0. 05 ） ; the apoptosis index after chemotherapy in CEF14 and CEF21 group was（24.00 ± 12.00） and （17.52 ±7.00）（P 〉0. 05）. There was statistical significance with the AIs in the two groups before and after the chemotherapy （ P 〈 0. 05 ）. Conclusion： Dose-dense neoadjuvant chemotherapy can achieve similar clinical results with routine neoadjuvant chemotherapy and induce the increase of apoptosis as efficiently as the routine neoadjuvant chemotherapy.