我院2005年临床分离菌菌群分布及耐药分析

Analysis of Bacterial Distribution and Drug Resistance in the 252nd Hospital of PLA in the Year 2005

目的:了解我院临床分离菌的分布及耐药情况,为指导临床合理用药提供参考依据。方法:采用Vitek-2全自动微生物分析仪及纸片扩散法(Kirby-Bauer)对2 024株分离菌进行鉴定及药敏实验。结果:2 024株分离菌中革兰阴性菌占53.6%,革兰阳性菌占36.0%,真菌占10.4%,金黄色葡萄球菌及凝固酶阴性的葡萄球菌中甲氧西林耐药株各占30.2%和34.4%。革兰阳性球菌中万古霉素抗菌活性最强,粪肠球菌对万古霉素耐药率为1.7%。革兰阴性杆菌中亚胺培南抗菌活性最强,铜绿假单胞菌对其有4.6%的耐药率;大肠埃希菌及肺炎克雷伯菌超广谱β-内酰胺酶的检出率为65.0%和40.0%。结论:本资料对临床治疗及抗生素药物的选用有参考价值。

Objective：To Analyze the bacterial distribution and resistance in the 252nd Hospital so as to advise the dosage in clinical practice. Methods ：The identification of bacteria and susceptibility test were performed using automatic bioanalysis-Vitek-2 and Kirby-Bauer methods. Results：Of 2 024 clinical isolates, gram negative organisms accounted for 53.6% , gram positive organisms for 36.0% ,and eumycete for 9.5%. In staphylococuus aureus （MRSA） and coagulase negative Staphylococuus ,MRSA and MRCNS accounted for 30.2% and 34.4% respectively. Vancomycin is the most potent antimicrobial agent against gram positive organisms with the resistant rate of Enterococcus faecalis at 1.7%. Imipenem is the most potent antimicrobial agent against gram negative bacilli with the resistant rate of Pseudomonas aeruginosa at 4.6%. The detection rate of Escherichia coli and Klebsiella pneumonlae were 65.0% and 40. 0% respectively in ESBI.,s. Conclusion ： The results can be helpful in reasonable choosing of antimicrobial agents in the treatment of infection caused by pathogenic bacteria.