[2,2]-对二甲苯环二体的合成研究

Synthesis of [2,2]-Paracyclophane

研究了季铵盐经霍夫曼消除反应制备[2,2]-对二甲苯环二体的合成方法。讨论了介质碱性、溶剂、反应温度和反应时间等工艺条件对产物收率的影响。获得了合成反应的优化参数为:对二甲苯为溶剂、硼氢化钠为还原剂、n(氧化银)∶n(季铵盐)=1∶1,反应温度110℃、反应时间10h。收率10.1%。

A synthetic method for the preparation of [2,2 ]-paracyclophane by hofmann elimination was proposed. The influences of medium alkalinity, solvents, reaction temperature and reaction time on the yield of the product were investigated. Suitable reaction parameters for the synthesis were obtained as follows： solvent was p-xylene, n （silver oxide）： n （quaternary ammonium salt）=1 ： 1, reaction temperature110℃ and reaction time 10 h. At this condition, the yield of [2,2 ]-paracyclophane was 10.1%, and the quality of the product met the standard of qualified product.