氯酯醒与三环抗抑郁药治疗抑郁症对照观察

A comparative study of meclofenoxane and tricyclic antidepressant in the treatment of depression

报告５１例抑郁症治疗的临床资料，分氯酯醒静滴组，三环抗抑郁药（ＴＣＡ）治疗组与二者并用共三组进行疗效的对照观察。结果表明：氯酯醒静滴治疗抑郁症有较好疗效，显效率７１．４％，有效率９２．９％。二者并用的显效率为８７．５％，有效率９１．７％，且见效快，能显著降低ＴＣＡ用量，减轻ＴＣＡ副反应。我们认为以氯酯醒静滴与ＴＣＡ并用治疗抑郁症是一种安全而有效的治疗措施。

bjective:To compare the antidepressant effect of meclofenoxane and tricyclic antidepressant.Method:51 depression patients were randomly divided into 3 groups and were given intravenous meclofenoxane,oral tricyclic antidepressant,and combined meclofenoxane and tricyclic antidepressant respectively.Results:Meclofenoxane reduced depression effectively in 92 9% of patients,of which 71 4% were markedly improved.The efficacy of combined therapy was 91 7%,of which 87 5% were markedly improved.Combined treatment had a faster onset of action.Discussion:This study suggests that the combined use of intravenous meclofenoxane and oral tricyclic antidepressant are effective in depression.The use of meclofenoxane can reduce the dosage of tricyclic antidepressant and thereby reduce the latters side effects.