急性肺动脉血栓栓塞症中白细胞介素-8水平的变化观察

The change of serum interleukin-8 in patients with acute pulmonary thromboembolism

目的:探讨致炎细胞因子(cytokine,CK)白细胞介素-8(interleukin-8,IL-8)在急性肺动脉血栓栓塞(acute pulmonary thromboembloism,APTE)中的作用。方法:APTE组23例,男性16例,女性7例,年龄21～78岁,平均(55.3±14.3)岁;对照组26例,男性19例,女性7例,年龄23～77岁,平均(54.6±15.2)岁。于溶栓前、溶栓后即刻,2h,8h和24h测IL-8水平。结果:与对照组比较,APTE组IL-8明显增高(P<0.001),并于溶栓后即刻和8h2次出现高峰,8h达最高峰值逐渐降低,至24h基本恢复溶栓前水平。结论:APTE可能引起IL-8介导的炎症、易栓反应,造成急性肺损伤,提示溶栓后继续抗凝、抗炎等干预治疗,并同时注意对内皮细胞的保护作用。

Objective： To investigate the effectiveness of interleukin-8 （IL-8） on acute pulmonary thromboembolism（APTE） .nethod：APTE was diagnosed in 23 patients （male 16, female 7, aged 55.3 ± 14.3）. There are 26 health cases in control group （male 19, female 7, aged 54.6 ± 15.2）. The venous blood was collected before and instant thrombolysis, 2 h, 8 h, 24 h after thrombolysis. The serum level was measured. Result：Compared with the control group, serum concentration of IL-8 increased significantly in APTE group（ P 〈 0.1301 ）. IL-8 appeared two pinnacles immediately and 8 h after thrombolysis. After up to the highest level at 8 h after thrombolysis, IL-8 went down to its original level at 24 h. Conclusion： APTE may induce acute lung injury through inflammation and prothrombolism mediated by IL-8. Our results indicated that anti-coagulation and anti-inflammation should be given after thrombolysis. Moreover we should emphasis on protecting the endothelium when pulmonary thromboembolism occurred.