摘要
自第一个质子泵抑制剂(PPI)奥美拉唑于1988年上市以来,PPI已成为酸相关性疾病治疗的首选药物。PPI抑制胃壁细胞泌酸的最终环节,抑酸能力大大超过H2受体拮抗剂等传统抑酸药,临床应用广泛。近年来PPI研发不断创新,新一代PPI在治疗胃食管反流病及其他酸相关性疾病时具有明显优势,起效更快,抑酸效果更好、更彻底,夜间酸突破短,药物代谢对CYP2C19酶的依赖性小,不受其基因多态性的影响。
Since the first proton pump inhibitor (Omeprazole) came into the market in 1988,PPIs have been omsidered as the drugs of first choice for treatment of patients with various acid-related diseases. PPIs block the final step of acid secretion of gastric parietal cells,and have much more potent action than traditional acid inhibitors,like 142-receptor antagonist.In the recent years,there are great development in the research of PPIs. The new-generation PPIs have outstanding advantages in the treatment of GERD and other acid-related diseases,with more rapid and effective inhibition of acid secretlon, shorter acid breakthrough in the night, and less dependence on the cytochromeP450 and gene polymorphism.
出处
《医学综述》
2007年第4期245-247,共3页
Medical Recapitulate
关键词
质子泵
质子泵抑制剂
酸相关性疾病
Proton pump
Proton pump inhibitor
Acid-related diseases