新生儿窒息后血浆内皮素-1和前列环素水平变化的研究

STUDY ON THE CHANGES OF PLASMA LEVELS OF ET-1 AND PGI_2 IN POSTASPHYXIA NEWBORNS

应用放射免疫方法测定、研究了健康新生儿33例和窒息新生儿56例的血浆ET－1和6－KetoPGF-1（PGI2稳定代谢产物）水平的动态变化。结果表明：（1）≤2天健康新生儿两种血浆浓度均显著高于生后8～9天组。（2）窒息新生儿两种血浆水平显著升高，与窒息的严重程度及窒息造成机体损害的严重度呈正相关；血浆ET－1与PGI。处于动态平衡，表现了内皮细胞水平的自身调节。（3）重庆HIE血浆ET－1下降甚缓慢，与PGI。处于失衡状态。本文讨论了ET－1与其相桔抗的PGI2。在国产期窒息病理生理过程中的作用。

篜lasma levels of ET-1 and 6-keto-PGF1.(a stable metabolite of PGI2) in 89 early neonates (33 healthyneonates and 56 postasphyxia newborns ) were determined by AIR method. The results showed: (1 ) Both theconcentrations in healthy neonates aged 2 days after birth were significantly greater than those in healthyneonates aged 8-9 days of ilfe. (2) both the levels in postasphyxia neonates were remarkably correlated between asphyxia and body damages resulted from asphyxia. There was a homeotasis between PGl2 and ET-1,indicating a feed back autoregular mechanism in vascular endothelial cell secretions. (3) both the cdncentra-tions declined to normal in 8-9 days of life with the recovery of the illness, but plasma levels of ET-l in in-fanTs with severe HIE decreased very slowly, which suggested that the PGl2 and ET-1 be out of balance. ThepaThophysiological roles for ET-1 and PGI2 in the course of perinatal asphyxia were were discussed