骨髓增生异常综合征患者外周血肿瘤坏死因子活性变化与预后的关系

Relationship Between Activity of TNF and Prognosis in Patients with Myelodysplastic Syndrome

采用生物学方法检测了１１例骨髓增生异常综合征（ＭＤＳ）患者治疗前后其体内肿瘤坏死因子（ＴＮＦ）活性变化。结果显示ＭＤＳ患者血清ＴＮＦ活性（５．９０±４．７６ｕ／ｍｌ）较正常人明显减低（１３．８７±７．５９ｕ／ｍｌ）（Ｐ＜０．０５），治疗后ＭＤＳ患者血清ＴＮＦ活性为９．３６±５．０７ｕ／ｍｌ，与治疗前比较差异显著（Ｐ＜０．０５）。研究结果还显示：在ＭＤＳ各亚型中，ＲＡ治疗后血清ＴＮＦ活性恢复明显高于ＲＡＥＢ和ＲＡＥＢ－Ｔ，提示ＴＮＦ活性变化对ＭＤＳ的病情变化及预后判断有重要临床意义。

The preipheral blood from 11 patients with myelodysplastic syndrome(MDS)was analysed for tumor nacrosis factor(TNF) activity(using bioassay method).The results showed that TNF activity was signiflcautly reduced in patients with MDS(5.90±4.76u/m) compared with the normal controls(13. 87±7.59u/ml)(P<0.05).TNF activity aft r treatment was significantly higher(9.36±5.07u/ml) than before treatment(P<0.05). The results showed that TNF activity of RA was much higher than that of RAEB and RAEB-T after treatment in MDS subtypes.The evidences suggested that the TNF activity has important clinical significance in the changes of the condition and progrosis.