Th细胞因子变化与妊娠高血压综合征关系的探讨

The relationship between the change of the Th Cytokine and the pregnancy-induced hypertension

目的探讨妊高征孕妇与正常孕妇细胞因子变化以及在发病机制中的作用。方法住院分娩的孕妇80例,其中妊高征50例(轻度19例、中度15例、重度16例),正常足月妊娠30例(对照组)。采集静脉血2ml,酶联免疫吸附试验检测血清中IL-2、IL-6、TNF-α浓度。结果TNF-α对照组浓度低于轻、中、重度妊高征组(P<0.05),IL-2对照组浓度低于中、重度妊高征组(P<0.05)。IL-6对照组浓度低于重度组(P<0.05);TNF-α/IL-6,IL-2/IL-6对照组与轻、中、重度妊高征组之间的差异无统计学意义(P>0.05)。妊高征患者TNF-α、IL-2、IL-6之间呈正相关性。结论妊高征孕妇体内细胞因子TNF-α、IL-2、IL-6浓度较正常孕妇体内升高,妊高征的发病与机体异常的机体异常的免疫激活,炎症状态有关有关。

Objective To study the difference of eytokine between the normal pregnancy and pregnancy induced hypertension （PIH）. Methods Peripberic blood and sere were obtained of 20 normal pregnancy and 50 PIH who were divided into three groups （ mild, moderate and severe ）. Cytokine of tumor necrosis factor-alpha （ TNF-α ）, interleukin-2 （ IL-2 ）, of interleukin-6 （ IL-6 ） were determined by using enzyme-linked immunosorbent assay （ELISA）. Results The serum concentrations of TNF-α were significantly higher in the group of PIH compared with the control group （ P 〈 0.05 ）. The serum concentrations of IL-2 were significantly higher in the moderate and severe group of PIH compared with the control group （ P 〈 0.05 ）. The serum concentrations IL-6 were significantly higher in the severe group of PIH compared with the control group （ P 〈 0.05 ）. The ratios of TNF/IL-6 and IL-2/IL-6 did not have significant differences between the control group and the PIH group（ P 〉 0.05 ）. Conclusion Cytokines of TNF-α,IL-2,IL-6 may be relevant in the pathogenesis of PIH.