IgG亚型与新生儿ABO溶血病的关系

The relationship of IgG subclasses and ABO hemolytic disease of newborn

目的探讨IgG亚型与新生儿ABO溶血病高胆红素血症的发生及危重程度的关系。方法对实验室诊断为新生儿ABO溶血病的患儿,用德国欧盟公司的亚型试剂盒测定其血清IgG亚型,并检测胆红素水平。结果153例实验室诊断为新生儿ABO溶血病的患儿中检测出IgG1和IgG3亚型的27例,其中24例发生高胆红素血症,检出IgG3亚型的全部发生高胆红素血症且胆红素增高明显。结论测定新生儿IgG亚型抗体,可有助于诊断新生儿ABO溶血病高胆红素血症的发生并预测其严重程度。

Objective Study the relationships of IgG subclasses and the risk of developing hyperbilirubinemia of newborns with ABO hemolytic disease. Methods We selected babies who were diagnosed as ABO hemolytic disease of newborn in laboratory, then tested their IgG subclasses and serum bilirubin levels. Results Among 27 newborns who had positive IgG1 or IgG3, 24 of them developed hyperbilirubinemia; all of the IgG3 positive newborns developed hyperbilirubinemia and their bilirubin level was significantly higher than that of IgG1 positive newborns. Conclusion IgG subclasses are helpful to diagnose hyperbilirubinemia of newborns with ABO hemolytic disease and to predict the severity of hyperbilirubinemia.