摘要
目的:研究低水平铅暴露对大鼠学习和记忆的影响。方法:0.05%水平醋酸铅污染大鼠饮用水28天,用Morris水迷宫试验测定大鼠的学习记忆功能。结果:在定位导航任务两组之间没有差异(P>0.05);在探索试验和工作记忆任务中,铅暴露组和正常对照组大鼠成绩显著差异(P<0.01)。结论:铅暴露对大鼠空间参考记忆和工作记忆有明显损害作用,对空间学习未见明显影响。
Objective： To develop a animal model of Pb-induced cognitive deficits for helping to further study of the underlying neural mechanisms after lead intoxication. Methods： An experiment was designed to investigate the effects of chronic low level lead exposure （0.05% of lead acetate to pollute their drinking water for 28 days） on the spatial learning and memory of rats by Morris water maze. Results： The results revealed low level Pb exposure significantly impaired spatial reference memory and spatial working memory of rats, but did not affect their spatial learning. Conclusion： The behavioral results revealed that lead intoxication does not affect the acquisition of a water maze task. However, there is a deficit in reference memory and working memory performance.
出处
《中国临床心理学杂志》
CSCD
2007年第1期88-91,共4页
Chinese Journal of Clinical Psychology
