激素引起股骨头缺血坏死中微循环障碍的实验和临床研究

Experimental and clinical stuties on microcirculation disturbance in the hormonal avascular necrosis of femoral head

目的用动物实验和临床试验方法找出激素引起股骨头坏死与微循环障碍的相关因素,探讨其发病机制,为预防和治疗提供理论依据。方法用糖皮质激素诱导出股骨头缺血坏死家兔模型,对比检测实验组和对照组的微循环状况,以及与微循环有关的毛细血管内血液流速,血液黏滞度、血液成分改变和组织病理学改变,探讨发病的主要相关因素。并按照实验结果采取相应的临床治疗,观察治疗效果是否支持实验结论。结果实验组毛细血管内血细胞集聚,血液流速明显缓慢,血脂和血浆蛋白含量增高,股骨头内毛细血管数量减少。通过抗凝和改善微循环治疗激素引起股骨头缺血坏死病例有效率达到93．7%。结论激素引起股骨头缺血坏死是微循环障碍性疾病。

Objective To find the correlation factors with microcirculation disturbance by animal and clinic exprements; making clear of the pathogenetic mechanism; and providing theoritical evidence for prevention and treatment of the disease. Methods The rabbits＇ femoral head avascular necrosis models were induced and created by corticoid steroids. The microcirculation including capillary blood flow rate, blood viscosity, blood ingredients and histopathologic change were studied comparatively between the experimental and the control groups in order to explore the correlative factors of the incidence and proper clinical treatment. Results The expremental group showed intracappillary blood cells aggregation, obviously slow down of blood flow, increase of serum cholesterol and protein, together with decrease of femoral head capillary vasculation. The effective rate for hormone induced femoral head avascular necrosis through anticoagulation and promotion of microvascular circulation reached 93.75%. Conclusion Hormone induced femoral head avascular necrosis is a kind of microcirculation disturbance disease.