胃动素动物实验及临床初步观察

RADIOIMMUNOASSAY OF MOTILIN IN RABBITS ,HEALTHY MEN AND PATIENTS WITH CHRONIC ATROPHIC GASTRITIS

对１３只兔右心室血浆、肠系膜上静脉血浆、胃液和十二指肠液及６７例健康人和慢性萎缩性胃炎（ＣＡＧ）患者血浆和十二指肠液胃动素（ＭＯＴ）含量的测定表明：１．兔十二指肠液、血浆与胃液ＭＯＴ的浓度比为４∶２∶１，三者间两两比较相差显著（Ｐ＜０．０５）；２．健康人血浆及十二指肠液ＭＯＴ含量分别为１４１．６±５７．３ｐｍｏｌ／Ｌ和３９５．１±１８０．４ｐｍｏｌ／Ｌ。后者是前者的２．８倍；３．ＣＡＧ患者血浆ＭＯＴ含量与健康组比较无显著性差异，十二指肠液的ＭＯＴ含量升高特别显著（Ｐ＜０．００１），且与萎缩及肠化程度有关。说明ＭＯＴ的分泌除有内分泌方式外，还有外分泌或腔内分泌途径，腔内分泌途径可能对维持与调节胃肠道局部运动功能有重要的生理及临床病理学意义。

The concentration of motilin in the plasma,gastric and duodenal juice of 13 male rabbits were measiured by using RIA, and so was the plasma and duodenal juice in 52 healthy men and 15 patients with chronic gastritis (CAG).Our study shows:(1)motilin concentration in duodenal juice is higher than in plasma,while that in gastric juice is the lowest (p< 0.05);(2) plasma and duodenal juice content of motilin in healthy subjects are 141. 6±57. 3pmol/L and 395.1± 180.4pmol/L(X±s) respectively (P<0.001).The Later is significantly higher than the former (P<0.001);(3)as for plasma levels of motilin there is no significant difference between CAG patients and healthy group (P> 0.05 ),but the content in duodenal juice of the former is significantly higer than that of the later (p<0.001).We conclude that Mo cells which secretes motilin may have the function of luminal secretion which may play an important role in physiology and the pathology of CAG.