胃、十二指肠溃疡患者内皮素Ⅰ水平初步探讨

Preliminary study of endothelin levels in patients with Gastric or duodenal ulcer

本文研究３２例胃、十二指肠溃疡患者血浆、胃液及胃、十二指肠溃疡缘与正常胃粘膜组织中内皮素Ⅰ的水平，并以１９例健康人作对照。结果表明：胃溃疡患者血浆内皮素Ⅰ水平为４．４８±０．７８ｐｇ／ｍｌ，明显高于健康对照组血浆水平２．５６±０．１７ｐｇ／ｍｌ，Ｐ＜０．０５。胃溃疡缘组织中内皮素Ⅰ含量为４１．６３±４．３６ｐｇ／ｍｇ，明显高于自身正常胃粘膜２１．８４±１．７３ｐｇ／ｍｇ和健康对照组内皮素Ⅰ含量２１．７８±１．６８ｐｇ／ｍｇ，Ｐ值均＜０．００１。提示内皮素Ⅰ可能作为局部因素参与胃溃疡的形成，并说明胃溃疡患者有血管收缩和舒张因子的代谢不平衡。而十二指肠溃疡患者血浆、胃液、组织中内皮素Ⅰ水平与健康对照组无明显差异，提示内皮素Ⅰ在十二指肠溃疡发病中并不起重要作用。

Endothelin(ET) levels of plasma Gastric juice ulcerative edge mucosa and normal Gastric mucosa in 32 patients with Gastric or duodenal ulcer were measured. Ninareen healthy subjects were as a control group. The results showed that ET level of plasma in the patients with Gastric ulcer was 4.48 ± 0.17pg/ml compared with healthy subject 2.56 ± 0.17pg/ml p< 0.05.ET level of Gastric ulcerative edge mucosa in subject group was significantly difference from ET level in itseif normal Gastic mucosa and in Gastric mucosa of contral group.(41.63±4.36pg/mg, vs 21.84±1.73pg/mg and 21.78±1.68pg/mg, p<0.001 ).This finding suggest that ET may play a local important role in the pathogenesis of Gastric ulceration. It also indicate that the patients with Gastric ulcer have a inbalance between the metabolism of endothelium-drived contracting and relaxing factors.The ET levels of the plasma,Gastric juice and ulcerative edge mucosa were no difference between the patients with duodenal ulcer and healthy Contral group.It suggest that ET may not play a important role in the pathogensis of duodenal ulceration.