活动期、愈合期及瘢痕期球溃疡患者胃酸及胃窦粘膜胃肠激素的变化

Abnormalitis Of Antral Mucosal Hormone Content And Acid Secre tion In Patients With Active,Healing And Scar Duodenal Ulcer

作者比较了活动期（ＡＤＵ）、愈合期（ＨＤＵ）及瘢痕期（ＳＤＵ）球溃疡（ＤＵ）患者和非溃疡对照（ＮＵ），患者的基础胃酸分泌量（ＢＡＯ）、高峰胃酸分泌量（ＰＡＯ）及胃窦粘膜内胃泌素（Ｇａｓ）、生长抑素（ＳＳ）、血管活性肠肽（ＶＩＰ）、Ｐ物质（ＳＰ）的含量。发现各期球溃疡患者ＰＡＯ均明显高于ＮＵ组；ＡＤＵ组胃窦粘膜Ｇａｓ及ＳＰ含量比ＮＵ组明显增加；ＳＤＵ组胃窦粘膜内ＳＳ较ＮＵ组明显增加。本文结果说明壁细胞泌酸能力增加是ＤＵ发病的重要病理生理基础，基础胃酸高分泌状态是ＤＵ患者溃疡活动的重要条件。ＡＤＵ患者ＢＡＯ增加与胃窦粘膜内Ｇａｓ增加有关。ＳＤＵ患者胃窦粘膜内ＳＳ有稳定基础胃酸分泌的作用。

The content of gastrin, somatostatin,VIP and substance P in antral mucosa and gastric acid secretion in patients with active,healing and scar duodenal ulcer was measured. Peak acid output(PAO)in all duodenal ulcer(DU)patients was higher than those of non-ulcer (NU).Compared to NU and scar duodenal ulcer (SDU) patients Basal acid ouput (BAO) in active duodenal ulcer (ADU)patients was significantly increased. Compared to NU The content of antral mucosal gastrin and Substance P(SP)in ADU patients was sigifcantly increased.The results suggested that in ADU patients the increase of BAO,which is relating to the increase of antral gastrin content,may contribute to the activity of DU. In SDU patients antral endogenous somatostatin may adjust acid secretory functin.