早幼粒细胞性白血病基因蛋白在喉癌和鼻咽癌中的表达及意义

Expression of PML in carcinogenesis of laryngocarcinoma and nasopharyngeal carcinoma

目的:探讨早幼粒细胞性白血病基因(PML)蛋白在喉癌和鼻咽癌组织中的表达及意义。方法:运用免疫组织化学SP法检测56例喉癌和34例鼻咽癌患者术后石蜡标本中PML蛋白的表达水平,分析其与肿瘤病理分级和T分级、淋巴结转移的关系。结果:①在不同病理分级的喉癌组织中,PML蛋白表达水平随着肿瘤恶性程度的升高而降低(P<0.05);②在不同T分级的喉癌和鼻咽癌组织中,PML蛋白表达水平随着肿瘤的发展而降低(P<0.05);③与喉癌组织相比,鼻咽癌组织中PML蛋白表达相对较低(P<0.05);④在有无淋巴组织转移的鼻咽癌组织和喉癌组织中PML蛋白表达均差异无统计学意义。结论:PML蛋白与喉癌和鼻咽癌的病理分级和T分级的关系密切,提示PML在抑制肿瘤生长中可起到一定的作用。在肿瘤的转移方面,PML所起作用较小。

Objective：To explore the significance of PML expression in carcinogenesis of laryngocarcinoma and nasopharyngeal carcinoma. Method： The PML expression in 56 laryngocarcinoma tissues and 34 nasopharyngeal carcinoma tissues were examined by immunohistochemitry. Moreover, the relationship between the PML expres- sion, with the pathologic grade,T stage and lymph node metastasis was analyzed. Result： The PML expression decreased with the ascending of pathological tumor grade（ P 〈0.05） and with the increasing of T grade of tumor （ P 〈0.05）. The expression of PML in nasopharyngeal carcinoma was lower than that in carcinoma of larynx （ P 〈0.05）. However, either in laryngocarcinoma or in nasopharyngeal carcinoma, there was no statistical difference on PML expression between with and without lymph node metastasis in laryngo carcinoma tisswes and nasopharyngeal carcinoma tissues. Conclusion： The close relationship between PML expression and the malignant parameters such as pathological grade and T grade of laryngocarcinoma and nasopharyngeal carcinoma, indicated that PML may play a role in cancer repression but not in cancer metastasis.