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喜树碱20S-羟基酯衍生物合成及抗肿瘤研究现状 被引量:2

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作者 潘显道
出处 《医学研究杂志》 2007年第2期14-16,共3页 Journal of Medical Research
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参考文献10

  • 1Wall ME,Wani MC,Cook CE.et al.Antitumor agent 1.the isolation and structure of camptothecin,a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminate.J Am Chem Soc,1966,88 (16):3888-3890
  • 2潘显道,王存英.天然抗肿瘤药喜树碱衍生物的研究进展[J].药学学报,2003,38(9):715-720. 被引量:30
  • 3Vishnuvajjala BR,Garzon-Aburbeh A.Water soluble prodrugs of camptothecin.US Patent 4943579,1990
  • 4Cao Z,Harris N,Kozielski A.et al.Alkyl ester of camptothecin and 9-nitrocamptothecin:synthesis,in vitro pharmacokinetics,toxicity,and antitumor activity.J Med Chem,1998,41:31-37
  • 5Cao Z,Giovanella BC.Aromatic esters of camptothecins and methods to treat cancers.US Patent 6228855,2001
  • 6Yang LX,Pan XD,Wang HJ.Novel camptothecin derivatives.Part 1:oxyalkanoid acid esters of camptothecin and their in vitro and in vivo antitumor activity.Bioorg Med Chem Lett,2002,12 (9):1241-1244
  • 7Yang X,Pan XD,Wang HJ.Nitrogen-based camptothecin derivatives.WO 02070525,2002
  • 8Pan XD,Han R,Sun PY.Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at 7-,10-and 20-positions.Bioorg Med Chem Lett,2003,13 (21):3739-3741
  • 9潘显道,陈晓光,等.20-位酯化的喜树碱衍生物及其制法和其药物组合物与用途.CN 1467210,2004
  • 10Conover CD,Greenwald RB,Pendri A,et al.Camptothecin delivery systems:the utility of amino acid spacers for the conjugation of camptothecin with polyethylene glycol create prodrugs.Anti-cancer Drug Des,1999,14:499-506

二级参考文献28

  • 1[1]Wall ME, Wani MC, Cook CE, et al. Antitumor agent I. The isolation and structure of Camptothecin, a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminata [J]. J Amer Chem Soc, 1966,88(16):3888-3890.
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  • 3[3]Liu LF, Desai SD, Li TK, et al. Mechanism of action of camptothecin [J]. Ann N Y Acad Sci, 2000,922:1-10.
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  • 7[7]Mitsui I, Kumazawa E, Hirota Y, et al. A new water-soluble camptothecin derivative, DX-8 951 f, exhibits potent antitumor activity against human tumors in vitro and in vivo [J]. Jpn J Cancer Res, 1995,86:(8)776-782.
  • 8[8]Luzzio MJ, Besterman JM, Emerson DL, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I [J]. J Med Chem, 1995,38(3):395-401.
  • 9[9]Lee JH, Lee JM, Lim KH, et al. Preclinical and phase I clinical studies with Ckd-602, a novel camptothecin derivative [J]. Ann NY Acad Sci, 2000,922:324-325.
  • 10[10]Verschraegen CF, Gupta E, Loyer E et al. A phase II clinical and pharmacological study of oral 9-nitrocamptothecin patents with refractory epithelial ovarian, tubal or peritoneal cancer [J]. Anticancer Drugs, 1999,10(4):375-383.

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