P15及P16蛋白在脑胶质瘤中表达的研究

Investigation on the Express of P15 and the P16 protein in the Brain Gliomas.

目的探讨抑癌基因p16、p15在脑胶质瘤中的表达及其与胶质瘤病理分级、恶性程度的关系。方法应用免疫组化sP方法检测63例人脑胶质瘤手术标本中P16、P15蛋白的表达水平。结果P16、P15蛋白的表达率与脑胶质瘤的病理分级呈负相关，且低恶性组（Ⅰ～Ⅱ级）与高恶性组（Ⅲ～Ⅳ级）相比较有显著差异（P〈0．001）。结论P16及P15蛋白的表达与胶质瘤的病理分级和恶性程度有关。从而可作为反映脑胶质瘤的增生能力及恶性进展的参考指标。

Objective To investigate cancer suppressor Genes p16, p15 in the brain gliomas expression and its relations with the gliomas pathology graduation and the malignant degree, Methods P16 and P15 protein expression level in human brain gliomas from 63 surgery specimens were assayed by immunobistochemical S - P method, Results P16, the P15 protein expression rate the brain gliomas pathology graduation assumes the inverse correlation with, also compared with the high malignant group the low malignant group （ Ⅰ- Ⅱ level） （ Ⅲ - Ⅳ level） has the remarkable difference （P 〈 0. 001）. Conclusions There are correlation between P16 and P15 protein expression and the gliomas pathology graduation and the malignant degree concerned. There for,P16 and P15 protein expression can be referred to the index of brain gliomas multiplication ability and the malignancy.