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HMGB-1病理生理作用的研究进展 被引量：4

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摘要 1999年Wang等报道高迁移率族蛋白-1（high mobility group box chromosomal protein 1，HMGB-1）是一种重要的晚期炎症介质参与了脓毒症的病理生理过程，并介导了内毒素的致死效应。此后，人们逐渐发现HMGB-1不仅在脓毒症中发挥重要作用，并且参与了多种病理生理过程。以下就HMGB-1的生物学特点及病理生理作用做一综述。
作者 孔瑞 孙备
机构地区 哈尔滨医科大学第一临床医学院肝胆胰外科
出处 《哈尔滨医科大学学报》 CAS 北大核心 2007年第1期82-84,共3页 Journal of Harbin Medical University
关键词 高迁移率族蛋白-1 生物学 病理学 生理学
分类号 Q51 [生物学—生物化学]
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参考文献25

  • 1Wang H,Bloom O,Zhang M,et al.HMG-1 as a late mediator of endotoxin lethality in mice[J].Science,1999,285 (5425):248-251.
  • 2Bustin M.Revised nomenclature for high mobility group(HMG) chromosomal proteins[J].Trends Biochem Sci,2001,26(3):152-153.
  • 3Li J,Kokkola R,Tabibzadeh S,Yang H,et al.Structural basis for the proinflammatory cytokine activity of high mobility group box 1[J].Mol Med,2003,9(1-2):37-45.
  • 4Wang H,Vishnubhakat JM,Bloom O,et al.Proinflammatory cytokines(tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes[J].Surgery,1999,126 (2):389-392.
  • 5Scaffidi P,Misteli T,Bianchi ME.Release of chromatin protein HMGB1 by necrotic cells triggers inflammation[J].Nature,2002,418 (6894):191-195.
  • 6Gardella S,Andrei C,Ferrera D,et al.The nuclear protein HMGB1 is secreted by monocytes via a non-classical,vesicle-mediated secretory pathway[J].EMBO Rep,2002,3(10):995-1001.
  • 7Andersson U,Wang H,Palmblad K,et al.High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in humanmonooytes[J].J Exp Med,2000,192(4):565-570.
  • 8Bonaldi T,Langst G,Strohner R,et al.The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding[J].EMBO J,2002,21(24):6865-6873.
  • 9Fiuza C,Bustin M,Talwar S,et al.Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells[J].Blood,2002,101(7):2652-2660.
  • 10Zetterstrom CK,Bergman T,Rynnel-Dagoo B,et al.High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid[J].Pediatr Res,2002,52 (2):148-154.

二级参考文献15

  • 1唐道林,肖献忠.热休克蛋白基因技术在心肌保护研究中的应用[J].国外医学（生理病理科学与临床分册）,2004,24(3):226-228. 被引量：4
  • 2Klosterhalfen B, Hauptmann S, Tietze L, et al. The influence of heat shock protein 70 on hemodynamic variables in a porcine model of recurrent endotoxemia[J].Shock,1997,7(5):358-363.
  • 3Villar J, Ribeiro SP, Mullen JB, et al. Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model[J].Crit Care Med,1994,22(6):914-921.
  • 4Snyder YM, Guthrie L, Evans GF, et al. Transcriptional inhibition of endotoxin-induced monokine synthesis following heat shock in murine peritoneal macrophages[J].J Leukoc Biol,1992,51(2):181-187.
  • 5Wang Y, Li C, Wang X, et al. Heat shock response inhibits IL-18 expression through the JNK pathway in murine peritoneal macrophages[J].Biochem Biophys Res Commun,2002,296(3):742-748.
  • 6Wang X, Zou Y, Wang Y, et al. Differential regulation of interleukin-12 and interleukin-10 by heat shock response in murine peritoneal macrophages[J].Biochem Biophys Res Commun,2001,287(5):1041-1044.
  • 7Wang H, Bloom O, Zhang M, et al. HMGB-1 as a late mediator of endotoxin lethality in mice[J].Science,1999,285(5425):248-251.
  • 8Schreiber E, Matthias P, Muller MM, et al. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells[J].Nucleic Acids Res,1989,17(15):6419.
  • 9Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation[J].Nature,2002,418(6894):191-195.
  • 10Fiuza C, Bustin M, Talwar S, et al. Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells[J].Blood,2003,101(7):2652-2660.

共引文献3

同被引文献344

引证文献4

二级引证文献15

哈尔滨医科大学学报
2007年 第1期

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