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肿瘤抑制因子PTEN蛋白在成年大鼠中枢神经系统的表达

Expression of tumor suppressor PTEN protein in central nervous system of adult rats
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摘要 目的观察PTEN在成年大鼠中枢神经系统(central nervous system,CNS)的表达情况。方法用免疫组织化学ABC法显示大鼠CNS中PTEN阳性免疫反应产物。结果PTEN阳性反应产物广泛分布于大鼠的CNS内,阳性细胞的分布主要表现为较多、中等量和少量3种情况,其亚细胞定位包括细胞质、细胞核和细胞质突起。结论明确PTEN在成年大鼠CNS中的表达模式。 Objective To investigate the expression characteristics of the phosphatase and tensin homolog deleted on the chromosome 10 （PTEN） in the central nervous system （CNS） of adult rats. Methods Immunohistochemical staining was used to demonstrate the PTEN-Iike positive immunohistochemical product. Results Expression of PTEN was extensive in the CNS. The distribution of positive cells was strong, moderate or weak and its subcellular localization included the cytoplasm, nuclei and processes. Conclusion The present results identify the expression of PTEN protein in the CNS of adult rats.
作者 蔡其燕 姚忠祥
机构地区 第三军医大学基础医学部组织学与胚胎学教研室
出处 《第三军医大学学报》 CAS CSCD 北大核心 2007年第5期384-386,共3页 Journal of Third Military Medical University
基金 国家自然科学基金(30572364)~~
关键词 PTEN 中枢神经系统 表达 the phosphatase and tensin homolog deleted on the chromosome 10 central nervous system expression
分类号 R322.81 [医药卫生—人体解剖和组织胚胎学] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献10

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二级参考文献7

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第三军医大学学报
2007年 第5期

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