血清ALP、GGT、AFU、5′-NT联合检查诊断肝病的价值

The clinical value of serum enzymatic activity in the diagnosis of hepatic carcinoma

目的:探讨血清中的酶对肝癌的诊断价值及联合检测的临床意义。方法:分别测定原发性肝癌组40例、转移性肝癌组30例、其它肝病组40例与、正常对照组40例血清标本中碱性磷酸酶(ALP)、γ-谷氨酰转移酶(GGT)、α-L-岩藻糖苷酶(A-FU)和5′-核苷酸酶(5′-NT),对结果进行统计学分析。结果:原发性肝癌组、转移性肝癌组中血清酶测定结果显著高于其它肝病组和正常对照组(P<0.05);ALP、GGT、AFU、5′-NT诊断肝癌(包括原发与转移)的阳性率分别为92.2%、91.4%、80.0%、75.7%,与其它肝病组的阳性率有显著性差异(P<0.05);ALP、GGT、AFU、5′-NT诊断肝癌的特异性分别为86.4%、82.5%、86.4%、87.5%。结论:联合检测血清中的酶对肝癌起预警作用,有助于肝癌的早期诊断。

Objective：To study the clinical value of serum enzymatic activity in the diagnosis of hepatic carcinoma. Methods. The activity of serum ALP,GGT,AFU and 5＇-NT was detected in 40 patients with primary hepatic carcinoma,30 patients with secondary liver cancer,40 patients with other kinds of hepatic disease and 40 normal persons. The all results were statistically analyzed. Results：The activity of serum ALP,GGT,AFU and 5＇-NT in patients with primary or secondary liver cancer was significantly higher than that of other kinds of hepatic disease and normal persons（P〈0.05）.The positive rate of ALP,GGT,AFU and 5＇-NT was 92.2%,91.4% ,80.0% and 75.7% respectively. At the same time,the specificity of ALP,GGT,AFU and 5＇ -NT was 86.4% ,82.5% ,86.4% and 87.5% respectively. Conclusions： To simultaneously detect the serum enzymatic activity can help to early diagnosis of hepatic carcinoma.