钩藤散浸膏对小鼠记忆障碍模型的影响

Effects of Goutengsan Extract on Mouse Models of Learning and Memory Disorders

目的观察钩藤散浸膏的益智作用。方法小鼠随机均分为6组,3个实验组每天灌胃高、中、低剂量的钩藤散浸膏,模型对照组与正常对照组每天灌胃蒸馏水(0.2 mL/10 g),阳性对照组每天给与茴拉西坦溶液(三乐喜,0.2 g生药/kg.bw),连续给药3周后,除正常对照组外,用东莨菪碱、亚硝酸钠、40%乙醇分别复制小鼠记忆获得障碍、记忆巩固障碍、记忆再现障碍模型,用Y型迷宫法测定小鼠训练和测试成绩。结果三种模型实验组的训练、测试成绩都显著好于模型对照组(P<0.01),记忆再现障碍模型的实验组测试成绩明显高于正常对照组(P<0.01)。结论钩藤散浸膏对各模型小鼠的记忆障碍皆有明显的改善作用,说明钩藤散浸膏有一定的益智作用。

Objective To evaluate the beneficial effects of a Chinese medicine, Goutengsan, on intelligence of mice. Methods Mice were randomly divided into 6 groups： 3 experimental groups, of which were daily administrated （ i. g. ） with Goutengsan extract at a high, middle and low dose, respectively. The model and control groups were administrated with distilled water, whereas mice receiving administration of aniracetam at 0.2 g/kg body weight served as a positive control. After continuous administration for 3 weeks, scopolamine, sodium nitrite, 40% ethanol were used to establish models of acquirement disorder, stability disorder and reappearance disorder of memory, respectively. The intelligence-promoting effect of Goutengsan extract was examined by Y-labyrinth method. Results The Goutengsan extract significantly improved the above-mentioned three memory hindrance models, especially in the group of reappearance disorder of memory. Conclusion The Chinese medicine Goutengsan can considerably improve the learning and memory capacities and show apparent intelligence-promoting effect in animal learning and memory disorder models.