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吡格列酮对糖尿病视网膜病变患者C反应蛋白的影响

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摘要 将184例2型糖尿病视网膜病变(DR)患者随机分为观察组和对照组,两组均采用常规治疗,观察组加用吡格列酮口服治疗,疗程20周。结果与治疗前及对照组治疗后相比,观察组血清C反应蛋白(CRP)水平明显下降(P<0.01)。认为DR发生与血清CRP密切相关,吡格列酮可通过降低CRP水平,对DR发挥治疗作用。
机构地区 日照市人民医院
出处 《山东医药》 CAS 北大核心 2007年第4期67-68,共2页 Shandong Medical Journal
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参考文献4

  • 1Freeman DJ,Norrje J.Caslake MJ,et al.C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study[J].Diabetes,2002,51(5):1596-1600.
  • 2杨照勇,荣海钦.C反应蛋白与代谢综合征[J].国外医学(内分泌学分册),2004,24(3):173-175. 被引量:58
  • 3van Hecke MV,Dekker JM,Nijpels G,et al.Inflammation and endothelial dysfunction are associated with retinopathy:theHoorn Study[J].Diabetoloqia,2005,48(7):1300-1306.
  • 4杨义生.噻唑烷二酮类药物改善胰岛素抵抗的分子机制[J].中国糖尿病杂志,2002,10(5):295-297. 被引量:24

二级参考文献32

  • 1Weyer C, Yudkin JS, Stehouwer CD, et al. Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis,2002,161:233-242.
  • 2Daniel G, Hackam MD, Sonia S. Emerging risk factors for atherosclerotic vascular disease. JAMA, 2003,290: 932-939.
  • 3Verma S, Li SH, Badiwala MV, et al. Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. Circulation, 2002,105:1890-1896.
  • 4Ridker PM, Rifai N, Rose L, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Eng J Med,2002,347,1557-1564.
  • 5Keller KB, Lemberg L. Obesity and the metabolic syndrome. Am J Crit Care, 2003,12:167-170.
  • 6Mortensen RF. C-reactive protein, inflammation, and innate immunity.Immunol Res, 2001,24:163-176.
  • 7Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation,2000, 102:2165-2167.
  • 8Venugopal SK, Devaraj S, Yuhanna I, et al. Demonstration that C-reactive protein decrease eNOS expression and bioactivity in human aortic endothelial cells. Circulation, 2002,106:1439-1441.
  • 9Festa AD, Agostino R Jr, Howard G, et al. Chronic subclinical inflammation as part of the insulin resistanee syndrome. Circulation, 2000,102:42-47.
  • 10Leinonen E, Hurt-Camejo E, Wiklund O, et al. Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes. Atherosclerosis, 2003,166: 384-394.

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