摘要
目的合成3,4,5-三甲氧基苄溴三苯基膦盐。方法以3,4,5-三甲氧基苯甲醛为原料,经过还原、溴代、加成三步反应得到叶立德前体3,4,5-三甲氧基苄溴三苯基膦盐。结果与讨论本工艺提高了收率,降低了成本,更加适合工业化生产。本工艺的总收率69.28%。
OBJECTIVE To synthesis 3,4,5-trimethoxy-triphenyl benzylidene bromide phosphine salt. METHODS 3,4,5-trimethoxy-triphenyl benzylidene bromide phosphine salt, the important precursor of the phosphine Ylide, was synthesis from deoxidize, bromization and addition. RESULTS and CONCLUSION The recycle rate was improved and the cost was lowered. This craft was suitful for industrial production. The total recycle rate can be improved to 70 percent by this technology.
出处
《齐鲁药事》
2007年第2期107-109,共3页
qilu pharmaceutical affairs
关键词
3
4
5-三甲氧基苄溴三苯基膦盐
叶立德
合成
3,4,5-trimethoxy-triphenyl benzylidene bromide phosphine salt
Ylide
synthesis
