Keggin结构杂多蓝配合物抗艾滋病病毒（HIV－1）活性研究（Ⅱ）

Studies on Anti-HIV-1 Activity of Heteropoly Blue Compounds with Keggin Structure

对钨磷、钨硅、铝磷、钼硅四种Ｋｅｇｇｉｎ结构杂多蓝进行了细胞毒性实验．抑制ＭＴ-４细胞增殖实验及抗艾滋病病毒活性实验．结果表明：Ｋｅｇｇｉｎ结构杂多蓝配合物具有较低的细胞毒性及较强的抗艾滋病病毒活性，其中钨硅和钨磷两电子杂多蓝对由艾滋病病毒引起的细胞病变作用（ＣＰＥ）具有较强的抑制活性，对ＣＰＥ的半数抑制浓度（ＥＣ５０）明显低于ｐＭ-１９．

The experiments on toxicity of MT-4 cell and restraining proliferation ofMT-4 cell and anti-HIV-1 activity with tungstophosphorate, tungstosilicate, molybdophosphorate and molybdosilicate heteropoly blue compounds of rear earth elementswith keggin structure were studied. The results show that heteropoly blue compounds ofrear earth elements with keggin structure are effective restraining agents with lowtoxcity of cell. In which Ze heteropoly blue compounds of tungstosilicate and tungstophosphorate possess high restraining activity on CPE caused by HIV--l. The half rastrainingconcentration to CPE (EC50) is less than that of PM-19.