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C-FLIP在喉癌中的表达及临床意义 被引量：1

Expression and Its Significance of c-FLIP in Laryngeal Carcinoma
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摘要 目的探讨c-FLIP(细胞型Fas相关死亡域样白介素-1β转换酶抑制蛋白)在喉癌组织中的表达及临床意义。方法应用免疫组织化学方法和流式细胞检测方法观察喉癌组织和声带息肉组织中c-FLIP表达情况。结果喉癌组c-FLIP阳性表达率为81%(35/43),声带息肉组c-FLIP阳性表达率为0%(0/10),两者比较具有非常显著差异(P<0.01)。c-FLIP表达与喉癌分期(早期与进展期)及淋巴结转移相关,染色度随喉鳞状细胞癌分期增高而增高并且有淋巴结转移的癌组织c-FLIP染色度,明显高于无淋巴结转移的喉癌组织。但与性别、年龄、肿瘤组织分级无明显关系。喉癌组与声带息肉组c-FLIP的平均荧光指数分别为4.73±0.74和1.06±0.18两者比较具有统计学意义(P<0.01)。结论c-FLIP在喉癌组织中表达增高,表明c-FLIP可能在喉癌的发生发展中起重要作用。 Objective To investigate the expression and its clinical significance of c - FLIP in laryngeal carcinoma. Methods The expression of c - FLIP protein in specimen＇s of 43 cases with laryngeal carcinoma and 10 cases with vocal cord polyps were studied with immunohistochemistry method and flow cytometry. Results Positive staining rate of c - FLIP in specimens of laryngeal carcinoma （81%） was significantly higher than that of vocal cord polyps （0. 0 % ） （P 〈 0. 001 ） . Furthermore, the expression level of c - FLIP was closely related to TNM stages and lymph node involvement , but not to histological classification and cell differentiation. The average fluorescence index of c - FLIP in laryngeal carcinoma and vocal cord polyps were 4. 73 ± 0. 74 and 1.06 ± 0. 18 （x± s） respectively （P 〈 0. 01 ） . Conclusions Overexpression of c -FLIP may play a crucial role in the carcinogenesis and progression of laryngeal carcinoma.
作者 李晶 王雪峰
机构地区 锦州医学院附属第一医院耳鼻咽喉科 锦州医学院附属第一医院
出处 《锦州医学院学报》 2006年第6期25-28,共4页 Journal of Jinzhou Medical College
关键词 喉肿瘤 癌 鳞状细胞 C—FLIP laryngeal neoplasms Carcinoma squamous cell c - FLIP
分类号 R739.65 [医药卫生—肿瘤]
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参考文献4

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二级参考文献8

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共引文献8

同被引文献18

  • 1彭志洋,曾飞.PEDF和C-FLIP在大肠癌组织中的表达及其临床意义[J].江西医学院学报,2009,49(5):95-98. 被引量：3
  • 2周晓东,于皆平,于红刚,罗和生,吕农华.胃癌组织中细胞FLICE抑制蛋白基因的表达研究[J].中华消化杂志,2005,25(1):10-14. 被引量：8
  • 3Bagnoli M,Canevari S,Mezzanzanica D.Cellular FLICE-inhibitory protein (c-FLIP) signalling: A key regulator of receptor-mediated apoptosis in physiologic context and in cancer.The International Journal of Biochemistry & Cell Biology,2010,42(2): 210-213.
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  • 6Lee T-J,Um H J,Min D S,et al.Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up- regulation of death receptor 5 and down-regulation of c-FLIP. Free Radical Biology and Medicine,2009,46(12): 1639-1649.
  • 7Chao X,Zao J,Xiao-Yi G,et al.Blocking of PI3K/AKT induces apoptosis by its effect on NF-[kappa]B activity in gastric carcinoma cell line SGC7901.Biomedicine & Pharmacotherapy,2010,64 (9):600-604.
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二级引证文献1

锦州医学院学报
2006年 第6期

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