上皮性钙黏附蛋白和α-连结素表达与胃癌生物学行为的关系

Relationship between Expression of Epithelial-C adherin,α-Catenin and Biological Behaviors of Gastric Cancer

目的研究上皮性钙黏附蛋白(E-cad)和α-连结素(α-Cat)的表达与胃癌生物学行为的关系。方法应用免疫组织化学SABC法分别检测76例胃癌及其相应正常胃黏膜组织中E-cad和α-Cat表达。结果胃癌组织中E-cad和α-Cat阳性表达率分别为46.1%和36.8%,均明显低于相应正常组织(P<0.01)。E-cad表达与胃癌分化程度及生长方式有关(P<0.01),且随着胃癌的分化程度降低,弥漫生长、浸润深度增加以及有淋巴结转移者α-Cat阳性表达率愈低(P<0.05或0.01)。结论E-cad和α-Cat表达下调伴随着胃癌的去分化和弥漫生长,且α-Cat表达异常与胃癌浸润转移密切相关。

Objective To evaluate the expressions of epithelial-cadherin （E-cad） and α-catenin （α-Cat） in gastric cancer and their relationship with the biological behavior. Methods The expressions of E-cad and α-Cat were detecled in tissue samples from 76 gastric cancers and their matched normal tissues by immunohistochemical method. Results The positive rates of E-cad and α-Cat in gastric cancers（45.8% ,36. 1% respectively） were significantly lower than those of normal tissues group（ P 〈0. 01 ）. E-cad expression significantly correlated with the differentia- ted degrees and growth pattern of the cancer（ P 〈 0. 05 ）. In gastric cancers, the rate of α-Cat expression significantly correlated with differentiated degrees ,growth pater depth of invasion and lymph node metastasis（ P 〈0. 05 or 0. 01 ）. Conclusion Down-regulation of E-cad and/or α-Cat indicates tumor poor differentiation and diffuse growth pattren, and the level of α-Cat may be a useful marker for the invasion and metastasis of gastric cancer.