骨髓间充质干细胞在肾小管间质纤维化大鼠肾脏中的定位与分布
被引量:3
摘要
肾小管间质纤维化(TIF)是几乎所有慢性肾脏疾病进展至终末期肾功能衰竭的主要原因之一,是临床治疗的难题。骨髓间充质干细胞(MSCs)是一类能够分化为多种骨髓间质成分的非造血多能干细胞,特定条件下可以分化为内胚层、脏壁中胚层和神经外胚层细胞。研究证实在急性肾脏损伤中MSCs可以被诱导分化成肾脏细胞,但在慢性肾小管间质纤维化中,移植的MSCs能否定位到损伤肾脏并分化为肾脏细胞、改善纤维化进程,还未检索到有关报道。本研究观察移植的MSCs在间质纤维化肾脏的定位分布及存活时间,为今后的研究提供理论依据。
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2007年第2期121-122,共2页
Chinese Journal of Nephrology
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