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肾素血管紧张素系统阻断剂的肾保护作用 被引量:41

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摘要 近年来大量研究揭示,体内肾素血管紧张素系统(RAS)过度激活在肾脏病慢性进展中发挥了十分重要的作用。以血管紧张素转换酶抑制剂(ACEI)和血管紧张素Ⅱ受体拮抗剂(ARB)为代表的RAS阻断剂通过降低血压、减少蛋白尿、抑制肾脏纤维化和延缓肾功能进展而发挥肾脏保护作用,已得到越来越多的临床和实验证实。但是随着对RAS研究的深入,RAS阻断剂临床应用中仍存在不少理论和实践问题,我们着重对其中最常见的10个问题,结合最新研究文献进行解答。
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2007年第2期129-133,共5页 Chinese Journal of Nephrology
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  • 1Horster MF, Braun GS, Huber SF.Embryonic renal epithelia: induction,nephrogenesis, and cell differentiation.Physiol Rev, 1999,79:1157-1191.
  • 2Ohashi R, Shimizu A, Masuda Y, et al. Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol, 2002,13: 1795-1805.
  • 3Wolf G, Ziyadeh FN. Molecular mechanisms of diabetic renal hypertrophy.Kidney Int, 1999,56: 393-405.
  • 4El Nahas AM, Muchaneta-Kubara EC,Zhang G, et al. Phenotypic modulation of renal cells in experimental and clinical renal scarring. Kidney Int, 1996, 49 Suppl 54: S23-S27.
  • 5Utsunomiya Y, Kawamura T, Abe A, et al. Significance of mesangial expression of α-smooth muscle actin in the progression of IgA nephropathy. Am J Kidney Dis, 1999,34: 902-910.
  • 6Ng YY, Fan JM, Mu W, et al.Glomerular epithelial-myofibroblast transdifferentiation in the evolution of glomerular crescent formation. Nephrol Dial Transpl, 1999, 14: 2860-2872.
  • 7Shankland SJ, Eitner F, Hudkins KL,et al. Differential expression of cyclindependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation. Kidney Int,2000, 58: 674-683.
  • 8Bariety J, Nochy D, Mandet C, et al.Podocytes undergo phenotypic changes and express macrophagic-associated markers in idiopathic collapsing glomerulopathy.Kidney Int, 1998, 53: 918-925.
  • 9Iwano M, Plieth D, Danoff TM. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest, 2002,110:341-350.
  • 10Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol, 2001, 159:1465 - 1475.

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