摘要
本研究系用麻风裸鼠实验模型，采用动力法投药１０５天，观察了０．０２％二甲胺四环素（美满霉素，ＭＩＮＯ）和０．０４％ＭＩＮＯ的抗麻风杆菌活性，并同０．０２％进口ＭＩＮＯ和已知抗麻风药物０．０２％利福平（ＲＦＰ）进行了平行比较。实验结果表明，国产ＭＩＮＯ儿进口ＭＩＮＯ的实验疗效基本一致，而且，随着药物剂量的提高，抑制麻风杆蓖作用增强。在停药早期，以０．０４％ＭＩＮＯ组疗效最佳，显示有部分杀菌活性，但是，随着停药时间的延长，ＡＦＰ比ＭＩＮＯ的抗菌活性稳定而持久。
The activitics of 0.02%and 0.04% homc-madc minocyclin ahainst M. leprae in the nude mice were cvaluat-cd by the kinetic method,and compared with those of 0.02% imported minocyclin and 0.02%rifampin. The nude mice weretreated for 105 days,The results revcalcd that the activity of home-made minocyclin against M. leprac is similar to that of im-ported minocyclin,and the larger the dosage of the drug is,the stronger the activity of the drug shows. During the early peri-od of stopping treatment,0.04% minocyclin showed the best anti-leprosy effect with the part of bactcriocidal activity.How-ever the activity of rifampin against M. leprae was more persistent and stablc than that of minocyclin when the period of stop-ping treatment is prolouged.
出处
《实验动物科学与管理》
1996年第3期34-36,共3页
Laboratory Animal Science & Administration
