摘要
目的:研究橙皮苷对皮肤色素沉着的抑制作用,为其治疗色素沉着性皮肤病提供实验依据。方法:选定橙皮苷、甘草提取物、甘草双胺盐及氢醌4种成分制成不同浓度的乳膏,制作棕黄色豚鼠经UVB照射诱导皮肤色素沉着的实验动物模型,采用苏木精-伊红、Schmorl、Imokawa等方法染色,观察外用中药后黑素细胞数量和形态的改变。结果:橙皮苷、甘草提取物、甘草双胺盐均使多巴阳性的黑素细胞及含黑素颗粒的细胞数较对照组明显减少(P<0.05),其中3%、4%橙皮苷与阳性对照组3%氢醌外用差异无统计学意义(P>0.05)。结论:橙皮苷、甘草提取物和甘草双胺盐对UVB诱导的色素沉着均具有抑制作用。
Objective： To investigate the inhibitory effects of hesperidin and glycyrrhiza on hypermelanosis and provide experimental evidence for treating skin pigmentary disorders. Methods： Four flavonoids with strong inhibitory effects on tyrosinase activity were tested. The changes of the number and morphology of melanocytes induced by UVB were observed in the experimental hypermelanosis model （brownish guinea pig） using HE, Schmorl and Imokawa staining. Results： Decreased melanocytes and melanin granules were found with the treatment of hesperidin and glycyrrhiza. Conclusion： There are inhibitory effects of hesperidin and glycyrrhiza on the hypermelanosis induced by UVB.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2007年第3期141-144,共4页
Journal of Clinical Dermatology
